现代检验医学杂志2016，Vol.31Issue(5)：84-87,4.DOI:10.3969/j.issn.1671-7414.2016.05.022
Toll样受体4和单核细胞趋化蛋白1与急性冠脉综合征的关系研究
Relation of Toll-like Receptor 4 and Monocyte Chemoattractant Protein-1 with Acute Coronary Syndrome
摘要
Abstract
Objective To investigate the relation of Toll-like receptor 4 (TLR4)and monocyte chemoattractant protein-1 (MCP-1)with acute coronary syndrome.Methods 60 patients with coronary heart disease patients including 39 cases of a-cute coronary syndrome (ACS group),21 cases of stable angina (SA group)from January 2015-March 2016 in Xi’an First Hospital were in this observation.ACS group was divided into acute myocardial infarction (AMI,n=21)and unstable angina pectoris (UAP,n=18).Another 30 cases with angiographically normal was included in control group.Enzyme-linked immu-nosorbent assay (ELISA)detection was used to detect the serum content of MCP-1,TLR4 expression was tested by flow cy-tometry.Triglyceride (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C)and high-density lipopro-tein cholesterol (HDL-C)were detected.Results TLR4 levels of ACS group was significantly higher than SA group (t=4.455,P=0.021).Serum MCP-1 levels of ACS group were significantly higher than SA group (t=3.220,P=0.002)and control group (t=6.197,P=0.000).MCP-1 levels of ACS group were higher than control group (t=2.306,P=0.025). The Spearman correlation test TLR4 was positively with MCP-1 (r=2.389,P=0.025).Conclusion MCP-1 and TLR4 may determine the severity of coronary heart disease,combined detection of MCP-1 and TRL4 can provide the clinical value for early diagnosis and treatment of ACS.关键词
Toll样受体4(TLR4)/单核细胞趋化蛋白 1(MCP-1)/急性冠脉综合征/稳定型心绞痛/不稳定型心绞痛/急性心肌梗死Key words
Toll-like receptor 4 (TLR4)/monocyte chemoattractant protein-1 (MCP-1)/acute coronary syndrome/unstable angina/acute myocardial infarction分类
医药卫生引用本文复制引用
王慧,王博,郭瑄..Toll样受体4和单核细胞趋化蛋白1与急性冠脉综合征的关系研究[J].现代检验医学杂志,2016,31(5):84-87,4.基金项目
陕西省社会发展科技攻关项目（2016SF339）。 （）
