现代检验医学杂志2016，Vol.31Issue(5)：91-93,96,4.DOI:10.3969/j.issn.1671-7414.2016.05.024
人类表皮生长因子受体2在乳腺癌表达与临床的相关病理特征分析
Expression of Human Epidermal Growth Factor Receptor 2 and Correlation with Clinical Pathological Features in Breast Cancer
摘要
Abstract
Objective To evaluate of value of HER2 as a prognostic marker,and to analysis associations with common his-topathological parameters in BC cases.Methods In this study,formalin-fixed,paraffin-embedded samples of tumors from 160 breast cancer patients who underwent curative surgery proce-dures between 2011 and 2014 were tested by immunohisto-chemistry (IHC)as aprimary estimate of HER2 status,followed by fluorescence in situ hybridization (FISH).Concordance rate between IHC and FISH was evaluated.Theχ2 test was used to evaluate the correlation between HER2 gene amplifica-tion status and different clinical pathological features including:(estrogen receptor)ER and (progesterone receptor)PR ex-pression,age,menopausal status and tumor size.Results There was a significant inverse association between expression of hormone receptors (ER and PR)and HER2 amplification (all P<0.05)among the patients studied.However,no relation-ship was observed between HER2 amplification and age,menopausal status and tumor size (P>0.05).HER2-negative le-sions were of higher grade and more likely to be ER-negative,PR-negative,p5 3-positive,lymph node metastasis,and also Ki-67≥20% as compared to the HER2-positive group and HER2 overe xpression was associated with the levels of ER and PR. Conclusion There is correlation of many clinical factors with HER2 expression.关键词
乳腺癌/表皮生长因子受体2/临床病理特征Key words
breast cancer/human epidermal growth factor receptor 2/clinical pathological features分类
医药卫生引用本文复制引用
刘延梅,马少君,张月浪,康晓丽,梁晓燕,周理乾,李文生..人类表皮生长因子受体2在乳腺癌表达与临床的相关病理特征分析[J].现代检验医学杂志,2016,31(5):91-93,96,4.基金项目
陕西社发科技攻关项目（编号2016SF-168），陕西科学技术研究发展计划项目（编号2013K-12-03-19）。 （）
