天津科技大学学报2016，Vol.31Issue(5)：47-51,5.DOI:10.13364/j.issn.1672-6510.20150087
炔雌醇多晶型非等温转晶动力学研究
Non-isothermal Kinetics of Polymorphic Transition of Ethinyl Estradiol
摘要
Abstract
Crystal form Ⅰof ethinyl estradiol was prepared through cooling crystallization and characterized by X-ray powder diffraction(XRPD),raman spectrometry and differential scanning calorimetry(DSC).Non-isothermal kinetics of ethinyl estradiol in the transformation process of crystal formⅠwas systematically investigated,using DSC technique.The results indicate that formⅠof ethinyl estradiol can be transformed into crystal formⅡunder heat mediated conditions.Based on the experimental data and different kinetic functions of corresponding polymorphic transition mechanism,the polymor-phic mechanism of ethinyl estradiol was analyzed and estimated.It is found that nuclei production and nuclei growth model, n=1/4,can best describe the ethinyl estradiol polymorphic transformation process.The corresponding mechanic functions of differential expression and the integral expression are f(α)=4(1-α)[-ln(1-α)]3/4 and G(α)=[-ln(1-α)]1/4,respectively.关键词
炔雌醇/多晶型/晶型转变/转晶动力学Key words
ethinyl estradiol/polymorphism/polymorphic transition/transformation kinetics分类
数理科学引用本文复制引用
李先朝,朱亮,王立宇,沙作良..炔雌醇多晶型非等温转晶动力学研究[J].天津科技大学学报,2016,31(5):47-51,5.基金项目
天津市应用基础与前沿技术研究计划资助项目(14JCZDJC40900) （14JCZDJC40900）
