现代医药卫生2016，Vol.32Issue(19)：2945-2948,4.DOI:10.3969/j.issn.1009-5519.2016.19.003
吸入一氧化氮治疗成人及儿童急性呼吸窘迫综合征并发症meta分析
Nitric oxide inhalation for treating adult and child acute respiratory distress syndrome complications:a meta analysis
摘要
Abstract
Objective To conduct a meta analysis on the nitric oxide (iNO) inhalation for treating adult and child acute respiratory distress syndrome(ARDS) complications in order to provide reference for its clinical application. Methods The pub-lished Chinese and English literatures on iNO inhalation for treating ARDS were searched by computer retrieval. With the occur rence rate of renal function injury,intracranial hemorrhage or periventricular leucomalacia (PVL),retinopathy of prematurity,cere-bral palsy,etc. as the observation indicators of end point efficacy,the odds ratio(OR) of merged curative effect and 95%confidence interval(95%CI) were obtained. Then the qualitative and quantitative comprehensive evaluation was performed. The qualified lit-eratures were evaluated by the inclusion and exclusion standards. Results (1)The renal function injury:the cases number in the iNO treatment group was higher than that in the control group,the difference was statistically significant(93 cases vs. 53 cases,P<0.05);intracranial hemorrhage or PVL:the difference between the iNO treatment group and the control group had no statistical significance(26 cases vs.39 cases,P>0.05);(2)nerve injury(cerebral palsy):the iNO treatment group was lower than the control group without statistical difference(6 cases vs. 9 cases,P>0.05);retinopathy:the iNO treatment group was lower than the control group without statistical difference(9 cases vs. 13 cases,P>0.05). Conclusion iNO for treating adult ARDS could increase the risk of renal impairment,therefore the use of iNO for treating ARDS adult patients with renal impairment is not recommended.关键词
一氧化氮/呼吸窘迫综合征,成人/急性呼吸窘迫综合征/并发症Key words
Nitric oxide/Espiratory distress syndrome,adult/Acute respiratory distress syndrome/Complications引用本文复制引用
刘亚男,江德鹏..吸入一氧化氮治疗成人及儿童急性呼吸窘迫综合征并发症meta分析[J].现代医药卫生,2016,32(19):2945-2948,4.基金项目
国家青年自然科学基金资助项目（81200028）。 （）
