摘要
Abstract
Objective To observe the efficacy and adverse reactions of docetaxel liposome combined with capecitabine (TX) in the treatment of elderly advanced 3-negative breast cancer(TNBC). Methods The clinical data in 54 cases of clinical stageⅢA~C,Ⅳof elderly advanced TNBC in this hospital from January 2013 to January 2015 were retrospectively analyzed. All patients were divided into the TX group and docetaxel liposome combined with cisplatin group (TP),27 cases in each group. TX group was given docetaxel liposome 150 mg/m2 by intravenous drip on 1 d and oral TX 1 000 mg/m2 on 1-14 d twice daily,meanwhile oral vitamin B6 30 mg,3 times daily,for preventing hand-foot syndrome,with 21 d as 1 cycle;the TP group was given docetaxel liposome 150 mg/m2 by intravenous drip on 1 d and cisplatin 25 mg/m2 by intravenous drip on 1-3 d,with 21 d as 1 cycle. The efficacy was evaluated after 2 cycles ,not more than 6 cycles. The short-term efficacy and adverse reactions were analyzed and compared between the two groups after finishing chemotherapy in all the cases. Results In the adjuvant chemotherapy of 54 cases of elderly advanced TNBC,the total effective rate was 68.5%(37/54),the effective rate in the TP group was higher than that in the TX group without statistical difference[63.0%(17/27)vs.74.1%(20/27),χ2=0.773,P=0.379];the occurrence rate of hand-foot syndrome in the TX group was significantly higher than that in the TP group,the difference was statistically significant(χ2=44.220, P=0.000),moreover the occurrence rates of nausea and vomiting in the TP group was significantly higher than that in the TX group,the difference was statistically significant(χ2=14.172,P=0.001);but the occurrence of hair loss,liver and kidney function abnormality and hematological toxicology had no statistically significant difference between the two groups (P>0.05). Conclusion In the adjuvant chemotherapy of clinical stageⅢA-C andⅣof elderly advanced TNBC,the TX regimen and TP regimen have the same short-term effect. The TX regimen alleviates the occurrence of gastrointestinal reactions ,but the occurrence of hand-foot syndrome is increased;therefore in that case of preventing this complication in advance ,the TX regimen may serve as one of adjuvant chemotherapeutic regimens in elderly advanced TNBC.关键词
乳腺肿瘤/脂质体/紫杉酚/卡培他滨/不良反应Key words
Breast neoplasms/Liposomes/Paclitaxel/Capecitabine/Side effects
