现代医药卫生2016，Vol.32Issue(20)：3103-3105,3.DOI:10.3969/j.issn.1009-5519.2016.20.003
苯并[a]芘对大鼠自主活动及运动协调能力的影响
Effects of benzo[a]pyrene on autonomic activity and motor coordination in rats
摘要
Abstract
Objective To explore the effect of subchronic exposure to benzo[a]pyrene (B[a]P) on autonomic activity and motor coordination in rats. Methods Thirty male juvenile rats,aged 3-4 d,were randomly divided into the blank group,solvent group(1.00 mL/kg plant oil),B[a]P low-dose group(0.02 mg/kg),B[a]P medium-dose group(0.20 mg/kg) and B[a]P high-dose group(2.00 mg/kg),6 cases in each group. After acclimatizing the feeding environment,the rats were intragastrically administrated for 7 consecutive weeks according to corresponding concentration. After exposure to toxicant ,the body weight of rat was measured. The open field test and foot printing test were conducted to evaluate the autonomic activity and motor coordination of rats ,respec-tively. The total number of crawling lattice ,up-right times and fecal particles number in the open field test were recorded. Mean-while,the heel footprints track in the foot printing test were also recorded. Results After exposure to toxicant,the growth and de-velopment of SD rats in each contamination group were delayed ,which showed that the body weight of each contamination group was significantly lower than that in the blank group and the total number of crawling lattice and upright times in each contamina-tion group was significantly increased when compared with the blank group and the solvent group , the difference was statistically significant (P<0.05). However,there were no statistically significant differences in the step width,step size,gait changes and an-gle changes among the five groups (P>0.05). Conclusion B [a]P can inhibit the growth and development of juvenile rats and promotes their autonomic activity,but has not obvious effect on the motor coordination.关键词
苯并芘类/毒性/神经行为学表现/自主活动/运动协调能力/大鼠,Sprague-DawleyKey words
Benzopyrenes/toxicity/Neurobehavioral manifestations/Autonomic activity/Motor coordination/Rats,sprague-dawley引用本文复制引用
粟秋平,杨凯,涂白杰..苯并[a]芘对大鼠自主活动及运动协调能力的影响[J].现代医药卫生,2016,32(20):3103-3105,3.基金项目
国家自然科学基金资助项目（81372957）。 （）
