现代医药卫生2016，Vol.32Issue(20)：3113-3115,3.DOI:10.3969/j.issn.1009-5519.2016.20.006
急性颅脑创伤后外周血SOD和MDA的变化
Changes of peripheral blood MDA and SOD levels after acute craniocerebral trauma
摘要
Abstract
Objective To investigate the role of superoxide dismutase(SOD) and malondialdehyde(MAD) for evaluating the severity and prognosis of acute craniocerebral trauma. Methods One hundred and twenty cases of acute craniocerebral trau-ma in the surgical first department of the Danyang Municipal Hospital of Traditional Chinese Medicine and the neurosurgery de-partment of Affiliated Hospital of Jiangsu University from January 2015 to January 2016 were selected and divided into the mild group [Glasgow Coma Scale(GCS) score 13-15 points],49 cases of moderate group(GCS score 9-12 points) and 23 cases of severe group(GCS score 3-8 points) according to the GCS score at admission. Thirty healthy staffs of the Danyang Municipal Hospital of Traditional Chinese Medicine in th physical examination were selected as the healthy control group. The peripheral blood SOD and MAD were detected in all the selected subjects. The peripheral blood SOD and MDA levels were detected at admission and on 3,7,14 d after admission in the patients with acute craniocerebral trauma; meanwhile the prognosis in the patients with acute craniocerebral trauma was evaluated at 3 months after trauma by using the Glasgow Prognosis Scale (GOS). One hundred and twenty cases were divided into the poor prognosis group(47 cases,GOS score 1-3 points) and good prognosis group(73 cases,GOS score 4-5 points). The differences of peripheral blood SOD and MDA levels were compared among various groups. The correlation be-tween peripheral blood MDA and SOD and between the GCS score at admission and GOS score at 3 months after trauma were ana-lyzed by adopting the Spearsman rank correlation test. Results The peripheral blood SOD level at admission and on 3,7,14 d after admission in the patients with acute craniocerebral trauma was decreased,while the MDA level was increased,which on 3 d after admission were most significant;the SOD level on 7 d began to pick up,the MDA level began to decline,which basically reached the normal level on 14 d. Among them ,the decrease of SOD level in the moderate and severe groups was faster than that in the mild group,and the elevation of MDA level was more significant than that in the mild group,the difference was statistically significant(P<0.01);the SOD and MDA levels at various time periods had no obvious change between the moderate group and the severe group,the difference was not statistically significant(P>0.05). The peripheral blood SOD level after trauma was positively correlated with the GCS score at admission and GOS score at 3 months after trauma (r=0.597 6,0.672 3,P<0.05);the peripheral blood MDA level on 3 d after trauma was negatively correlated with the GCS score at admission and GOS score at 3 months after trauma(r=-0.485 6,-0.436 4,P<0.05). The SOD level and MDA level showed a negative correlation(r=-0.784 3,P<0.05). Con-clusion Monitoring the change of SOD and MDA levels after craniocerebral trauma is of great significance to assess the severity and prognosis of craniocerebral trauma and has a guiding significance for its clinical treatment.关键词
超氧化物歧化酶/丙二醛/颅脑损伤/预后/随机对照试验Key words
Superoxide dismutase/Malondialdehyde/Craniocerebral trauma/Prognosis/Randomized con-trolled trial引用本文复制引用
李宝东,陈冬云,谢建勤,殷桥,陶玉峰,杨来华,吴旻,陈泽军..急性颅脑创伤后外周血SOD和MDA的变化[J].现代医药卫生,2016,32(20):3113-3115,3.基金项目
江苏省镇江市科技支撑计划（社会发展）指导性项目（FZ2014051）。 （）
