新医学2016，Vol.47Issue(10)：666-670,5.DOI:10.3969/j.issn.0253-9802.2016.10.004
16例新分类大细胞肺癌的临床病理分析
Clinicopathologic characteristics of large cell lung carcinoma according to the WHO new histological classification
摘要
Abstract
Objective To analyze clinicopathologic characteristics of idiopathic large cell lung carci-noma (LCLC)according to WHO new histological classification of lung cancer.Methods According to the 2015 WHO histological classification,clinical data of 16 LCLC cases were reviewed.The histopathologic char-acteristics,clinical manifestations,treatment and prognosis were observed.Results All 16 histological speci-mens were positive for HCK and negative for PAS staining.Fifteen patients were male and one female,aged 64 (range 48-79)years on average.Based upon the TNM staging system,2 cases were stage Ⅰ,1 stage Ⅱ,5 stage Ⅲ and 8 stage Ⅳ.Thirteen cases (81%)were classified as the advanced stage (stage Ⅲ-Ⅳ).The mean maximum diameter of tumor was 3.6 (range 1.1-7.3)cm.Five patients had brain metastases,2 presen-ted with neck lymph node metastases and one vertebral metastasis.Imaging examination revealed that 13 cases (81.3%)were peripheral type nodules.Thirteen patients (81.3%)were smokers.Eight patients underwent lobectomy combined with postoperative chemotherapy,5 received resection of brain metastasis tumor and chem-otherapy,2 resection of neck lymph node metastasis tumor combined with chemotherapy,and 1 resection of vertebral metastasis tumor plus chemotherapy.The median survival was 10.5 months.The 1-,2-and 3-year survival rate of all cases were 38%,38% and 25%,respectively.Conclusions LCLC is a type of rare, highly-invasive,poor differentiated and highly malignant tumor.LCLC patients present atypical clinical charac-teristics.Currently,clinical therapies for LCLC are limited.Early diagnosis and surgical resection remain the optimal choice.关键词
大细胞肺癌/肺癌/临床病理分析Key words
Large cell lung carcinoma/Lung cancer/Clinicopathologic features引用本文复制引用
王康玮,陈少红,杨静,刘国荣,杜洪,魏树全..16例新分类大细胞肺癌的临床病理分析[J].新医学,2016,47(10):666-670,5.基金项目
广东省医学科学技术研究基金 （）
