针刺研究2016，Vol.41Issue(5)：469-473,5.DOI:10.13702/j.1000-0607.2016.05.020
基于细胞因子的针刺治疗类风湿关节炎的镇痛、抗炎机制研究进展
Development of Researches on Cytokine Mechanisms in Analgesia and Anti-inflammation in Acu-puncture Therapy for Rheumatoid Arthritis
摘要
Abstract
Cytokines are closely related to the occurrence and development of rheumatoid arthritis(RA).Acupuncture exerts anti-inflammatory and analgesic effects via elevating anti-inflammatory cytokine level and reducing pro-inflammatory cyto-kine level and regulating Th 1/Th 2 balance,which reflects the dual directional regulatory effect of acupuncture.However,prob-lems exist in the current researches,such as inadequate depth,limited breadth and not so up-to-date research focus.The medio-cre research level and the phenomena of some contradictory results among studies also need being concerned.Therefore,pro-gress may be attained if a holistic,dynamic and networked study is conducted on the influence of acupuncture on cytokines by combining the latest progress in the mechanisms of network of cytokines and neuroendocrine immune network,and high throughput cytokine capture assay.In this way,the mechanism of cytokines in multi-targets (such as local joints,peripheral blood circula-tion,central nervous system)involving the effects of acupuncture in improving RA will be known more.关键词
针刺/细胞因子/镇痛/抗炎/类风湿关节炎/佐剂性关节炎Key words
Acupuncture/Cytokine/Analgesic effect/Anti-inflammation/Rheumatoid arthritis/Adjuvant arthri-tis分类
医药卫生引用本文复制引用
洪寿海,丁沙沙,张阔,徐媛,赵雪,宣丽华,郭义..基于细胞因子的针刺治疗类风湿关节炎的镇痛、抗炎机制研究进展[J].针刺研究,2016,41(5):469-473,5.基金项目
国家自然科学基金重点项目(No.81330088) （No.81330088）
浙江省中医药科技计划项目(No.2016 ZA 081) （No.2016 ZA 081）
