摘要
Abstract
Background and objective Due to it's concealment and no obvious symptoms, lung squamous carcimoma otfen has advanced disease when diagnosed. hTe aims of this study were to describe the characteristics of the disease, to evaluate the clinical importance of detection of multiple tumor markers in patients with squamous cell carci-noma of the lung.Methods hTe characteristics of all patients with advanced squamous cell lung cancer treated in Beijing Cancer Hospital of Chinese Academy of Medical Sciences during Jan. 2011 to Dec. 2015 were identiifed by cases review-ing and data extracting. hTe characteristics, detection levels and sensitivity of multiple tumor makers among patients were described.Results hTe 260 patients were treated with mean age of (59.4±9.2) years, 85.8% (n=223) of them were male, 14.2% (n=37) of them were female. 78.1% (n=203) of all were smokers and 3.1% (n=8) of patients had family history of tumor. hTe positive rate of cytokerantin 19 fragment (CYFAR21-1) was 71.2%, which was the highest among ifve tumor markers. hTe ifve tumor markers median level had no statistical signiifcance between different tumor (T) stages and node (N) stages (allP>0.05), only the positive rate of SCC had statistical signiifcance between different T stages (P=0.035). hTe combination measurement of CYFRA21-1+carcinogen-embryonic antigen (CEA), CYFRA21-1+CEA+cancer antigen (CA125), CA125+CYFAR21-1+CEA+neuron speciifc enolase (NSE), and CA125+CYFAR21-1+NSE+CEA+squamous cell carcinoma antigen (SCC) were better and had higher clinical values, the positive rates were 82.7%, 84.6%, 85.0% and 86.2%, respectively.Conclusion hTe positive rate of CYFAR21-1 was the highest and the sensitivity of single test of ifve tumor markers was low, the combination of multiple tumor markers increased the sensitivity of diagnosis of SQCLC, the combination of CA125, CYFAR21-1 and CEA was the best choice.关键词
肺鳞癌/临床特征/肿瘤标志物/阳性率Key words
Squamous cell lung cancer/Clinical characteristics/Tumor markers/Sensitivity
