中国实用外科杂志2016，Vol.36Issue(10)：1096-1100,5.DOI:10.7504/CJPS.ISSN1005-2208.2016.10.20
腹腔镜胃旁路术与药物治疗肥胖合并2型糖尿病疗效比较分析
Outcomes of laparoscopic Roux-en-Y gastric bypass and medical therapy in obese patients with type 2 diabetes
摘要
Abstract
Objective To observe and evaluate therapeutic results of laparoscopic Roux-en-Y gastric bypass (LRYGB) and medical therapy for the patients of obesity with type 2 diabetes mellitus (T2DM). Methods A randomized controlled trial was conducted among the 180 obese patients with T2DM who were selected from Tianjin Nankai Hospital (107 cases) and Tianjin Medical University Metabolic Diseases Hospital (73 cases) from 2010 to 2013. The 180 cases were randomly divided into LRYGB group and medical therapy group (90 cases per group). The 3 years follow-up outcomes of BMI,%EWL and data about diabetes were analyzed. Results There were 87 (96.7%) and 88 (97.8%) cases who were observed and followed up for 3 years in each group. The operations were successful in LRYGB group. After 3-year follow up, in the LRYGB group, the BMI changed from 39.5 ± 3.7 to 29.3 ± 6.2;%EWL was (66.0 ± 7.3)%;the glycosylated hemoglobin (HbA1c) changed from (8.6 ±3.0)%to (6.8±2.0)%;the fast blood glucose (FBG) changed from (9.6 ±2.8) mmol/L to (7.2 ±3.5) mmol/L. In medical group, BMI changed from 38.8 ±6.0 to 38.2 ±6.7;%EWL was (3.8 ± 6.2)%;the HbA1c changed from (9.0 ± 3.6)%to (8.5 ± 3.8)%;the FBG changed from (9.7 ± 3.3)mmol/L to (9.3 ± 3.1) mmol/L. The differences of outcomes regarding obesity and diabetes were significant statistically(P<0.05). Conclusion The short term effect of LRYGB in obesity and T2DM is reliable and superior to the medical therapy. Diabetes remission rate of LRYGB is 64.4%, without any severe complications. LRYGB is an effective method which can be used to treat the Chinese obese patients with T2DM.关键词
肥胖/2型糖尿病/腹腔镜胃旁路术/随机对照研究/短期随访Key words
obesity/type 2 diabetes mellitus/laparoscopic Roux-en-Y gastric bypass/randomized controlled trial/short term follow-up分类
医药卫生引用本文复制引用
张辰,赵宏志,钱东,于珮,王庆,王震宇,蔡旺,孙喆,秦鸣放..腹腔镜胃旁路术与药物治疗肥胖合并2型糖尿病疗效比较分析[J].中国实用外科杂志,2016,36(10):1096-1100,5.基金项目
天津市科学技术委员会国际科技合作项目 （）
