中国畜牧兽医2016，Vol.43Issue(10)：2640-2647,8.DOI:10.16431/j.cnki.1671-7236.2016.10.019
SIGIRR对IL-1R/TLRs信号通路的负性调控作用研究进展
Research Progress on the Negative Regulatory Function of SIGIRR to IL-1R/TLRs Signal Pathway
摘要
Abstract
Single immunoglobulin IL-1 related receptor (SIGIRR)is a member of TIR superfami-ly.Recent evidences suggested that it could negatively modulate ILRs/TLRs-mediated innate im-mune response,and in particular its important role focused from infectious and intestinal inflam-mation to autoimmunity or cancer-related inflammation had been illuminated.Here,we summa-rized our current understanding of the expression patterns of SIGIRR gene and protein in differ-ent specises including human,mouse and bovine,its downregulate function of the IL-1/TLRs sin-gal pathway and specific negative regulation mechanism ascribed to its structure specificity,and also its elaborate regulating process related to the occurrence and development of different patho-gen condition.And then it can not only provide theoretical references for clinical inflammatory re-lated disease,but also broaden the application scope of SIGIRR gene in the treatment of animal diseases.关键词
SIGIRR/TLRs/信号通路/负性调控Key words
SIGIRR/TLRs/signal path/negative regulation分类
生物科学引用本文复制引用
周秋格,刘畅,刘玉辉,赖金伦,陈颖钰,郭爱珍,胡长敏..SIGIRR对IL-1R/TLRs信号通路的负性调控作用研究进展[J].中国畜牧兽医,2016,43(10):2640-2647,8.基金项目
国家肉牛/牦牛产业技术体系(nycytx-382662016PY015)；宁夏肉牛呼吸疾病综合征及皮肤病防控技术研究与示范(2012ZDN0903)；中央高校基本科研业务费专项资金(2662015PY054)；湖北省自然科学基金项目(2015CFB435) （nycytx-382662016PY015）
