中国药房2016，Vol.27Issue(29)：4091-4092,4093,3.DOI:10.6039/j.issn.1001-0408.2016.29.18
促红细胞生成素对脑损伤早产儿神经功能及脑干听觉诱发电位的影响
Effects of Erythropoietin on Nerve Function and Brainstem Auditory Evoked Potential in the Preterm Chil-dren with Brain Damage
摘要
Abstract
OBJECTIVE:To investigate the effects and safety of erythropoietin on nerve function and brainstem auditory evoked potential in the preterm children with brain damage. METHODS:46 preterm children with brain damage were randomly di-vided into treatment group and control group,with 23 cases in each group. Control group received conventional symptomatic treat-ment as respiratory support,nutritional support,vitamin K supplement and ganglioside. Treatment group was additionally given rhE-PO for injection (CHO cell) 500 IU/kg hypodermically,3 times a week,on the basis of control group. Both group received 3-4 weeks of treatment continuously. MDI,PDI,the content of serum nerve injury factor(NSE,S-100β),latent period and peak inter-val of brainstem auditory evoked potential were compared between 2 groups before and after treatment,and the occurrence of ADR was observed in 2 groups. RESULTS:There was no statistical significance in MDI,PDI,the content of serum nerve injury mole-cule,latent period and peak interval of brainstem auditory evoked potential between 2 groups before treatment (P>0.05). After treatment,MDI and PDI of 2 groups increased significantly,while the content of serum nerve injury factor,latent period and peak interval of brainstem auditory evoked potential decreased significantly;the treatment group was better than the control group,with statistical significance (P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Erythropoietin can significantly im-prove intelligence development,protect the damaged nerve cells and auditory nerve pathways with good safety.关键词
早产儿/促红细胞生成素/脑损伤/脑干听觉诱发电位/神经细胞Key words
Preterm children/Erythropoietin/Brain injury/Brainstem auditory evoked potential/Nerve cell分类
医药卫生引用本文复制引用
王玉,孙东明,姬静璐,柏金秀,杨小巍,李晨,安娜..促红细胞生成素对脑损伤早产儿神经功能及脑干听觉诱发电位的影响[J].中国药房,2016,27(29):4091-4092,4093,3.基金项目
河北省医学科学研究重点课题计划 （）
