中国药房2016，Vol.27Issue(29)：4096-4098,3.DOI:10.6039/j.issn.1001-0408.2016.29.20
双黄连注射液治疗慢性阻塞性肺疾病急性加重期患者的临床观察
Clinical Observation of Shuanghuanglian Injection in the Treatment of Acute Exacerbation of Chronic Ob-structive Pulmonary Disease
摘要
Abstract
OBJECTIVE:To evaluate the clinical efficacy of Shuanghuanglian injection in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD),and to observe its effects on the plasma levels of C-reactive protein (CRP),procalcitonin(PCT)and interleukin-6(IL-6). METHODS:A total of 100 AECOPD patients were randomly divided into observation group and control group,with 50 cases in each group. Control group received routine treatment,such as controlled oxygen therapy,intravenous dripping of moxifloxacin,bronchodilator for relieving asthma,mucolytic for eliminating phlegm,nu-tritional support. Observation group was additionally given Shuanghuanglian injection 1 ml/(kg·d)added into 5% Glucose injec-tion 250 ml intravenously,qd,on the basis of control group. Treatment course of 2 groups lasted for 10 d. Clinical efficacies of 2 groups were compared as well as the changes of serum levels of CRP,PCT and IL-6 before and after treatment and the occur-rence of ADR. RESULTS:After treatment,total effective rate of observation group was 96.0%,which was significantly higher than 82.0% of control group,with statistical significance(P<0.05). Before treatment,there was no statistical significance in se-rum levels of CRP,PCT and IL-6 between 2 groups (P>0.05). After treatment,serum levels of CRP,PCT and IL-6 were de-creased significantly in 2 groups,and those of observation group were significantly lower than those of control group,with statis-tical significance (P<0.05). There was no statistical significance in the incidence of ADR between 2 groups (P>0.05). CON-CLUSIONS:Shuanghuanglian injection can effectively improve serum inflammatory factors of AECOPD patients,and shows good clinical efficacy and safety.关键词
双黄连注射液/慢性阻塞性肺疾病急性加重期/C反应蛋白/降钙素原/白细胞介素-6/临床疗效Key words
Shuanghuanglian injection/Acute exacerbation of chronic obstructive pulmonary disease/C-reactive protein/Pro-calcitonin/Interleukin-6/Clinical efficacy分类
医药卫生引用本文复制引用
赵振寰,荆伟丽,姜艳,隋忠国,董海..双黄连注射液治疗慢性阻塞性肺疾病急性加重期患者的临床观察[J].中国药房,2016,27(29):4096-4098,3.基金项目
青岛市民生科技计划（人口与健康）项目 （）
