中国药房2016，Vol.27Issue(29)：4136-4138,3.DOI:10.6039/j.issn.1001-0408.2016.29.34
冻干重组人脑利钠肽治疗急性失代偿性心力衰竭的临床观察
Clinical Observation of Recombinant Human Brain Natriuretic Peptide on Acute Decompensated Heart Failure
隋韶光 1孙雷 1刘宇飞 1崔明 1李向东1
作者信息
- 1. 大连医科大学附属第二医院急诊科，辽宁大连 116033
- 折叠
摘要
Abstract
OBJECTIVE:To observe therapeutic efficacy and safety of recombinant human brain natriuretic peptide (rhBNP) in the treatment of acute decompensated heart failure (ADHF). METHODS:129 ADHF patients admitted in our hospital during Jul. 2013-Jul. 2015 were randomly divided into observation group(69 cases)and control group(60 cases). Control group was giv-en routine treatment. Observation group was additionally given rhBNP 1.5 μg/(kg·d)vein shock(d1),and then rhBNP 1 mg+5%Glucose injection 100 ml by 0.007 5 μg/(kg·min),ivgtt(d2-4). Treatment courses of 2 groups lasted for 7 d. Therapeutic efficacy and heart function indexes [left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVDd)] were observed in 2 groups as well as NT-proBNP level,medication fluid intake and urine volume 24 h after medication. The occurrence of ADR was observed. RESULTS:3 cases dropped out and 66 cases were included finally in doservation group. Total effective rate of AD-HF therapy in observation group (96.97%) was significantly higher than in control group (86.67%),with statistical significance (P<0.05). There was no statistical significance in LVEF,LVDd and NT-proBNP between 2 groups before treatment(P>0.05). Af-ter treatment,LVEF of 2 groups were increased significantly while LVDd were decreased significantly;LVEF of observation group [(42.3±3.6)%] was significantly higher than in control group[(37.9±3.3)%],while LVDd of observation group [(55.5± 3.6)%] was significantly lower than in control group[(61.3 ± 3.4)%]. NT-proBNP levels of 2 groups were decreased significant-ly,and the observation group [(1 389.5±29.6)pg/ml] was significantly lower than the control group [(2 778.0±26.8)pg/ml]. 24 h after medication,urine volume of 2 groups were significantly higher than medication fluid intake,and urine volume of observation group [(1 781.4 ± 89.7)ml] was significantly higher than that of control group [(1 372.6 ± 78.3)ml],with statistical significance (P<0.05). There was no statistical significance in the incidence of ADR between observation group (3.03%) and control group (5.00%),without statistical significance(P>0.05). CONCLUSIONS:rhBNP is significantly effective for ADHF,promotes heart function recovery and reduces renal function injury with good safety.关键词
冻干重组人脑利钠肽/急性失代偿性心力衰竭/心功能/疗效/N-末端脑钠肽原Key words
Recombinant human brain natriuretic peptide/Acute decompensated heart failure/Heart function/Efficacy/NT-proBNP分类
医药卫生引用本文复制引用
隋韶光,孙雷,刘宇飞,崔明,李向东..冻干重组人脑利钠肽治疗急性失代偿性心力衰竭的临床观察[J].中国药房,2016,27(29):4136-4138,3.
