中国药理学通报2016，Vol.32Issue(10)：1333-1336,4.DOI:10.3969/j.issn.1001-1978.2016.10.001
2型糖尿病骨质疏松研究进展
The research progress of type 2 diabetes osteoporosis
摘要
Abstract
Diabetes is a kind of metabolic syndrome, always hap-pening in the case of insufficient secretion of insulin or insulin resistance, inducing the increase of blood glucose. While, dia-betic osteoporosis is a kind of chronic diabetic complications, which happens when insulin secretion is absolutely or relatively insufficient and then the insufficiency induces imbalance of hor-mone, calcium phosphorus metabolic disorders, thus leading to the decline of bone mineral density and change of bone micro-structure. The overnutrition, less exercise and the environment change lead to the increased incidence of diabetes. For all the diabetes, type 2 diabetes accounts for about 90%. Patients with type 2 diabetes show the increasing risk of fracture. This review summarizes the recent advances in the influence of type 2 diabe-tes on bones.关键词
2型糖尿病/骨质疏松/高糖/胰岛素/药物/炎症因子Key words
2 diabetes/osteoporosis/high glucose/insulin/drugs/Inflammatory cytokine分类
医药卫生引用本文复制引用
刘帼静,呼晓雷,何发忠,张伟..2型糖尿病骨质疏松研究进展[J].中国药理学通报,2016,32(10):1333-1336,4.基金项目
国家自然科学基金资助项目( No 81273595) （ No 81273595）
国家高技术研究发展计划(863计划)资助项目(No 2012AA02A518) （863计划）
