中国药理学通报2016，Vol.32Issue(10)：1337-1340,4.DOI:10.3969/j.issn.1001-1978.2016.10.002
维生素D对骨髓基质干细胞成骨分化的分子调控研究进展
Research progress on molecular regulatory effects of vitamin D on osteogenic differentiation of bone marrow stromal cells
摘要
Abstract
Marrow stromal cells ( MSCs) , component of the mar-row stroma, play an important role in the growth of bone and metabolic balance. This paper mainly summarizes and reviews the molecular regulaory effects of vitamin D and its active form 1, 25 dihydroxy vitamin D3[1,25(OH)2D3] on the osteogenet-ic differentiation of MSCs by Wnt signaling pathway, Wnt5a/ROR2 axis, BMP/TGF-β/Samd signaling pathway and ROS/ERK signaling pathway, so as to clarify the molecular signaling pathway through which vitamin D regulates MSCs metabolically.关键词
维生素D/1,25(OH)2D3/骨髓基质干细胞/分子调控/信号通路/成骨分化Key words
vitamin D/1,25(OH)2D3/marrow stromal cells/molecular regulation/signaling pathway/osteogenic differentia-tion分类
医药卫生引用本文复制引用
张尧,李晓莉,张岩..维生素D对骨髓基质干细胞成骨分化的分子调控研究进展[J].中国药理学通报,2016,32(10):1337-1340,4.基金项目
国家自然科学基金资助项目( No 81202894) （ No 81202894）
龙医创新团队计划项目(No LYCX-01) （No LYCX-01）
