中国药理学通报2016，Vol.32Issue(10)：1341-1344,4.DOI:10.3969/j.issn.1001-1978.2016.10.003
甲基苯丙胺诱导神经细胞自噬的研究进展
Research progress of methamphetamine inducing nerve cell′s autophagy
摘要
Abstract
Methamphetamine ( METH ) , a powerful stimulant of amphetamine type in the central nervous system ( CNS ) , is a new kind of synthetic drugs mainly in psychological dependence. Long-time abuse will lead to strong neurotoxicity and drug de-pendence. Recently it has become the abuse problem in public health. Autophagy is a process of degradation and utilization of the cellular components by the lysosome, which widely exists in eukaryotic cells. Many studies show that methamphetamine can iduce autophagy,but the underlying mechanism is not fully un-derstood yet . Therefore,the mechanisms and signaling pathways of autophagy by methamphetamine and the roles of autophagy in methamphetamine induce neurotoxicity are reviewed in this pa-per, so as to provide reference materials for further research of methamphetamine and autophagy.关键词
甲基苯丙胺/自噬/神经毒性/神经细胞/机制/信号通路Key words
methamphetamine/autophagy/neurotoxicity/nerve cell/mechanism/signaling pathway分类
医药卫生引用本文复制引用
杨根梦,陈逊,曾晓锋..甲基苯丙胺诱导神经细胞自噬的研究进展[J].中国药理学通报,2016,32(10):1341-1344,4.基金项目
国家自然科学基金项目(No 81560303 （）
81660310) （）
云南省科技厅-昆明医科大学应用基础研究联合专项( No 2013FB127) （ No 2013FB127）
云南省科技厅-昆明医科大学应用基础研究联合专项(No 2016FB129) （No 2016FB129）
云南省重大传染病疫苗研发重点实验室开放研究基金项目(No KF2015-01) （No KF2015-01）
