中国药理学通报2016，Vol.32Issue(10)：1348-1352,5.DOI:10.3969/j.issn.1001-1978.2016.10.005
β淀粉样蛋白跨血脑屏障转运机制研究进展
Research progress on transport mechanism of amyloid beta-peptides across blood-brain barrier
摘要
Abstract
Amyloid beta-peptides ( Aβ) is the key pathological feature of Alzheimer’s Disease (AD). Various factors contrib-ute to the accumulations of Aβ in the brains of patients. Among them, blood-brain barrier ( BBB) plays a crucial role in trans-porting Aβ between the brain and the bloodstream while this transfer function is mediated by the receptor of Aβon BBB. The abnormality of Aβ transport and related receptor expression can be detected in the brains of patients with AD, resulting in an un-usual increase in Aβlevels unusually increased . This review e-laborates the structure and function of BBB, the transport of Aβand the expression and transport mechanism of the related recep-tor, as well as summarizes the possible clearance strategy of Aβacross the BBB.关键词
β淀粉样蛋白/阿尔茨海默病/血脑屏障/转运/晚期糖基化终末产物受体/低密度脂蛋白受体相关蛋白Key words
amyloid beta-peptides/Alzheimer ’ s Disease/blood-brain barrier/transport/receptor for advanced glycation end-products/low-density lipoprotein receptor-related protein分类
医药卫生引用本文复制引用
张海静,赵春晖,张文生..β淀粉样蛋白跨血脑屏障转运机制研究进展[J].中国药理学通报,2016,32(10):1348-1352,5.基金项目
国家自然科学基金资助项目( No 81274118) （ No 81274118）
国家科技部“重大新药创制”科技重大专项资助项目( No 2012ZX09103-201) （ No 2012ZX09103-201）
中央高校基本科研业务费项目( No 2015KJJC A05) （ No 2015KJJC A05）
