摘要
Abstract
Objective To investigate synthetic antibacterial peptide in antibacterial properties of oral bacteria.Methods 9 kinds of synthetic antibacterial peptide(Brevinin,chensinin-1,chensinin-1b,L-K5V1,L-K6,L-K6V1, L-K6V2 and temporin lcea,Temporin-1CEb)and 6 kinds of oral bacteria(Candida albicans,Fusobacterium nucleatum, Lactobacilus acidophilus,Streptococcus mutans,Streptococcus salivarius,Streptococcus sanguinis)were used to vitro experiment.Synthetic antibacterial peptide in antibacterial properties of oral bacteria was analyzed.Results Chensinin-1b,L-K5V1,L-K6,L-K6V1,L-K6V2,Temporin-1CEa had high inhibitory rate with Candida albicans.Brevinin, chensinin-1b,L-K5V1,L-K6,L-K6V1,L-K6V2,Temporin-1CEa,Temporin-1CEb had high inhibitory rate with Fusobacterium nucleatum,Streptococcus mutans,Streptococcus salivarius,Streptococcus sanguinis.Brevinin,chensinin-1,chensinin-1b, L-K5V1,L-K6,L-K6V1,L-K6V2,Temporin-1CEa,Temporin-1CEb had high inhibitory rate with Lactobacilus acidophilus. Minimum inhibitory concentrations of Brevinin:Streptococcus sanguinis>Fusobacterium nucleatum>Streptococcus salivarius>Streptococcus mutans>Lactobacilus acidophilus.Minimum inhibitory concentrations of chensinin-1: Lactobacilus acidophilus.Minimum inhibitory concentrations of chensinin-1b:Lactobacilus acidophilus>Streptococcus salivarius>Streptococcus sanguinis>Fusobacterium nucleatum>Candida albicans>Streptococcus mutans. Minimum inhibitory concentrations of L-K5V1:Lactobacilus acidophilus>Fusobacterium nucleatum>Streptococcus mutans>Candida albicans>Streptococcus salivarius>Streptococcus sanguinis.Minimum inhibitory concentrations of L-K6:Streptococcus salivarius>Streptococcus sanguinis>Candida albicans>Streptococcus mutans>Fusobacterium nucleatum>Lactobacilus acidophilus.Minimum inhibitory concentrations of L-K6V1:Lactobacilus acidophilus>Streptococcus sanguinis>Streptococcus salivarius>Candida albicans>Fusobacterium nucleatum> Streptococcus mutans.Minimum inhibitory concentrations of L-K6V2:Candida albicans>Streptococcus mutans>Streptococcus salivarius>Lactobacilus acidophilus>Fusobacterium nucleatum>Streptococcus sanguinis.Minimum inhibitory concentrations of Temporin-1CEa:Candida albicans>Fusobacterium nucleatum>Streptococcus salivarius>Lactobacilus acidophilus>Streptococcus mutans>Streptococcus sanguinis.Minimum inhibitory concentrations of Temporin-1CEb:Streptococcus salivarius>Fusobacterium nucleatum>Streptococcus mutans>Streptococcus sanguinis>Lactobacilus acidophilus.Conclusion Different synthetic antimicrobial peptides on the antibacterial performance of oral bacteria is different,the minimum inhibitory concentration of Temporin-1CEa is smal,and the inhibitory effect is good.关键词
人工合成抗菌肽/口腔细菌/抗菌性能Key words
Synthetic antibacterial peptide/Oral bacteria/Antibacterial property分类
医药卫生
