中国医学装备2016，Vol.13Issue(10)：125-127,3.DOI:10.3969/J.ISSN.1672-8270.2016.10.037
手十二井穴刺络放血对急性一氧化碳中毒意识障碍大鼠促醒作用及其机制的研究
Study on the mechanism of promoting awakening of twelve well points of the hand pricking blood therapy on acute carbon monoxide poisoning consciousness disorder rats
摘要
Abstract
Objective:To observe the effect of needling hand twelve wells phlebotomy poisoning glutathione peroxidase activity of rat consciousness, venous blood carboxyhemoglobin concentration and brain tissue of acute carbon monoxide.Methods: A total of 30 adult male SD rats were randomly divided into normal group, model group and treatment group, with 10 rats in each group. In rats exposed before and immediately exposed after 1 hour and 4 hours, we observed the state of consciousness of rats and tested venous blood carboxyhemoglobin contents. The brain tissue was taken out after 4 hours, to detect glutathione peroxidase activity.Results: Twelve well points of the hand pricking blood in rats with acute carbon monoxide poisoning can improve the state of consciousness and shorten the duration of coma. After exposed for 1 hour and 4 hours, carboxyhemoglobin concentration in rat tail vein blood in the treatment group was significantly higher than that in the model group. The glutathione peroxidase activity in the brain tissue of the treatment group was significantly higher than that of the model group after exposed for 4 hours.Conclusion: Twelve well points of the hand bloodletting has protective effect on brain of rats with acute carbon monoxide poisoning coma.关键词
急性一氧化碳中毒/井穴放血/碳氧血红蛋白/谷胱甘肽过氧化物酶Key words
Acute carbon monoxide poisoning/Blood-letting puncture at Jing-points/Carboxyhemoglobin/Glutathione peroxidase分类
医药卫生引用本文复制引用
岳颖,金军,刘建卫,刘亮,刘文淑,冯宇,郭义..手十二井穴刺络放血对急性一氧化碳中毒意识障碍大鼠促醒作用及其机制的研究[J].中国医学装备,2016,13(10):125-127,3.基金项目
国家自然科学基金(81303023)“基于p38信号通路的井穴放血法对急性一氧化碳中毒的脑保护作用机制研究”；天津市科学技术委员会自然科学基金资助项目(08JCYBJC27700)“手十二井穴刺络放血急救煤气中毒的临床与实验研究” （81303023）
