中国卒中杂志2016，Vol.11Issue(10)：836-841,6.DOI:10.3969/j.issn.1673-5765.2016.10.005
脑出血患者经颅多普勒超声评估颅内压变化研究
Study on Intracranial Pressure Changes with Transcranial Doppler Ultrasound in Patients with Intracerebral Haemorrhage
吴建维 1贾娇坤 1丁则昱 1赵性泉1
作者信息
- 1. 100050 北京首都医科大学附属北京天坛医院神经病学中心，国家神经系统疾病临床医学研究中心，脑血管病转化医学北京市重点实验室
- 折叠
摘要
Abstract
Objective To further verify the correlation between intracranial pressure (ICP) and blood flow parameters of transcranial Doppler ultrasound (TCD) in patients with cerebral hemorrhage. The optimal mathematical models of intracranial pressure were established, which were predicted quantitatively by blood lfow parameters of TCD, and then evaluated the accuracy. <br> Methods According to the inclusion and exclusion criteria, demographic data, major neurological function scores and characteristics of lesions of 22 patients with cerebral hemorrhage were registered. The intracranial pressure monitor was used to monitor the intraparenchymal pressure continuously at the bedside. TCD detection was reviewed daily. The blood lfow parameters of MCA and ICA, the instant ICP values, temperature, blood pressure, heart rate, and oxygen saturation were recorded. The analyses of multiple linear regression were completed to establish the optimal mathematical model of ICP evaluated by TCD parameters, and then evaluate the accuracy for the diagnosis of intracranial hypertension (ICP>15 mmHg). <br> Results The correlation analysis of PI and ICP showed positive correlation, and the correlation coefficient wasr=0.66 (P<0.01). The mathematical model was ICPe=-16.8+26.8×PI+0.12×Vm, adjusted R2=0.46; When ICP>15 mmHg, the area under curve of ICPe was 0.93, and 95% conifdence interval was 0.88-0.97. <br> Conclusion PI is positively correlated with ICP, and is the most important predictive indicator of the ICP evaluation. ICPe=-16.8+26.8×PI+0.12×Vm (adjusted R2=0.46) could predict the ICP to diagnose the intracranial hypertension (ICP>15 mmHg) with high accuracy.关键词
脑出血/颅内压/经颅多普勒超声/搏动指数Key words
Cerebral hemorrhage/Intracranial pressure/Transcranial Doppler/Pulsatility index引用本文复制引用
吴建维,贾娇坤,丁则昱,赵性泉..脑出血患者经颅多普勒超声评估颅内压变化研究[J].中国卒中杂志,2016,11(10):836-841,6.
