中国卒中杂志2016，Vol.11Issue(10)：857-862,6.DOI:10.3969/j.issn.1673-5765.2016.10.009
认知行为疗法联合抗抑郁药物治疗卒中后抑郁的系统评价
Effectiveness of Cognitive Behavioral Therapy with Antidepressants on Post-stroke Depression：a Systematic Review
摘要
Abstract
Objective To assess the effectiveness of cognitive behavioral therapy with antidepressants on post-stroke depression. <br> Methods All published research about randomized controlled trials (RCTs) focusing on cognitive behavioral therapy with antidepressants on post-stroke depression on PubMed, Cochrane library, CNKI, VIP, Wanfang Standards Database were searched. Meta-analysis was conducted by RevMan 5.3 software based on data which was eligible for inclusion criteria. The improvement condition of Hamilton Depression Scale (HAMD) and rehabilitation status of neuro-function by Fugl-Meyer Motor-Function Scale were analyzed to compare the effectiveness of two therapies. <br> Results A total of 9 RCTs were included, involving 584 post-stroke depression patients. The results of meta-analysis of the subgroup of early phase (4 weeks, 8 weeks) and long-term phase (12 weeks, 21 weeks, 52 weeks) revealed that cognitive behavioral therapy with antidepressants was more effective in decreasing depression score than control group (4 weeksWMD -1.42, 95% conifdence interval [CI] [-2.02,-0.78],P<0.001; 8 weeksWMD -3.74, 95%CI [-5.50,-1.99],P<0.001; 12 weeksWMD -1.86,95%CI [-2.55,-1.17],P<0.001; 21 weeksWMD -2.20, 95%CI [-3.09,-1.30],P<0.001; 52 weeksWMD-3.73, 95%CI [-4.75,-2.70],P<0.001), and the results also showed that cognitive behavioral therapy with antidepressants was more effective in motor function rehabilitation than control group (WMD-0.32, 95%CI [-0.60, -0.04],P=0.03). <br> Conclusion Cognitive behavioral therapy with antidepressants on post-stroke depression is more effective in decreasing depression score, and promotes the motor functional recovery of patients.关键词
卒中后抑郁/认知行为疗法/抗抑郁药物/系统评价Key words
Post-stroke depression/Cognitive behavioral therapy/Antidepressants/Systematic review引用本文复制引用
李丽君,胡卫疆,高雅坤,陈琦,张宁,王春雪..认知行为疗法联合抗抑郁药物治疗卒中后抑郁的系统评价[J].中国卒中杂志,2016,11(10):857-862,6.基金项目
脑重大疾病数据的采集规范及挖掘分析研究，北京市科学技术委员会资助（Z151100003915117）脑白质疏松患者跌倒风险预警评估工具的构建及临床验证研究，首都特色 （）
