滨州医学院学报2016，Vol.39Issue(5)：321-323,326,4.
硫化氢对慢性应激抑郁模型大鼠行为及海马SOD活力和MDA含量的影响
The effect of hydrogen sulfide on the behavior and SOD activity and MDA content of hippocampus in rats with chronic stress depression
摘要
Abstract
Objective To observe the effects of hydrogen sulfide (H2 S) on the behaviors ,SOD (superoxide dismutase ,SOD) activity and MDA (malonaldehyde ,MDA ) content of hippocampus in chronic stress depression rats .Methods Healthy male Wistar rats were randomly separated into normal control group ,CUMS group ,CUMS + L‐NaHS group ,CUMS + H‐NaHS group .A rat depression model was induced by CUMS .Behaviors of rats were assessed by forced swimming test and UV spec‐trophotometer analysis technique was used to detect SOD activity and MDA content of hippocampus .Results Immobility time of rat in forced swimming test increased ,SOD activity decreased and MDA content increased in the CUMS group rats .NaHS treatment could partly reverse these changes .Conclusion NaHS ,the donor of H2 S ,could relieve the depression induced by CUMS in rats ,and the mechanism may be correlated to increasing the antioxidative stress ability of rats .关键词
硫化氢/抑郁症/超氧化物歧化酶/丙二醛/氧化应激Key words
hydrogen sulfide/depression/superoxide dismutase/malonaldehyde/oxidative stress分类
医药卫生引用本文复制引用
刘红霞,王华,于腊梅,郭莉..硫化氢对慢性应激抑郁模型大鼠行为及海马SOD活力和MDA含量的影响[J].滨州医学院学报,2016,39(5):321-323,326,4.基金项目
山东省自然科学基金（ZR2013HL009）；烟台市科技发展计划项目 （）
