重庆医学2016，Vol.45Issue(30)：4252-4254,4258,4.DOI:10.3969/j.issn.1671-8348.2016.30.024
MGMT 不同表达水平的恶性胶质瘤患者术后采用不同化疗方案的疗效分析
Efficacy of different chemotherapy regimens for patients with malignant glioma on different expression levels of MGMT
摘要
Abstract
Objective To investigate the differences of clinical efficacy and untoward reaction of different chemotherapy regi‐mens for patients with malignant glioma on different expression levels of O6‐methylguanine‐DNA‐methyltransferase(MGMT) ,in order to provide references for clinical treatment .Methods Totally 90 cases of patients with malignant glioma in our hospital from January 2011 to January 2013 were selected ,among them ,64 cases of MGMT negative expressing patients were divided into group A and group B with 32 cases in each group ,and 26 cases of MGMT positive expressing patients were enrolled into the group C . Group A was treated with combination of radiotherapy ,teniposide and nimustine ,group B was treated with radiotherapy‐temozolo‐mide combination regimen ,group C was treated with combination of radiotherapy ,teniposide and nimustine .The untoward reactions of the three groups were compared ,and the survival rate was observed after one year follow‐up .Results The hemoglobin ,leuko‐cyte ,granulocyte ,platelet ,bleeding ,alanine aminotransferase ,creatinine ,urea nitrogen ,peripheral neuritis ,untoward reactions a‐mong the three groups had no statistically significant differences (P>0 .05);the incidence rates of nausea and vomiting ,diarrhea , constipation among the three groups had statistically significant differences(P<0 .05) ,in which group C was significantly higher than that of group A and group B(P<0 .05) .Only one case in the group C was lost in the one year follow‐up .The median survival time was 10 months in group A and group B ,and was 7 months in group C .The median survival time in group C was significantly lower when compared with that in group A and group B(χ2 =7 .673 ,P=0 .006 ;χ2 =6 .395 ,P=0 .011) ,while there was no signifi‐cant difference of median survival time between group A and group B(χ2 =0 .063 .P=0 .802) .Conclusion The long‐term prognosis of patients with negative MGMT expression might be significantly worse than that of patients with negative MGMT expression in glioma .关键词
六氧甲基鸟嘌呤-DNA甲基转移酶/胶质瘤/化疗/不良反应Key words
O6-methylguanine-DNA-methyltransferase/glioma/chemotherapy/untoward reaction分类
医药卫生引用本文复制引用
袁江伟,杨洁,宋玉芝,王玉祥..MGMT 不同表达水平的恶性胶质瘤患者术后采用不同化疗方案的疗效分析[J].重庆医学,2016,45(30):4252-4254,4258,4.基金项目
河北省卫生厅青年科技项目（20130245）。 （）
