摘要
Abstract
Objective To explore the difference of some RA-related cytokines and other clinical indices of dampness-heat blockage syndrome and cold-dampness blockage syndrome. We try to find some objective indicator that may be helpful for the syndrome differentiation of RA. Methods Eighty cases of RA patients of the outpatient and inpatient department were enrolled in the study. The patients were divided into dampness-heat blockage syndrome and cold-dampness blockage syndrome according to syndrome differentiation. Blood test was conducted to detect IL-1β, IL-2R, IL-6, IL-8, IL-10, tumor necrosis factor α, rheumatoid factor; erythrocyte sedimentation rate, C-reactive protein, anti-cyclic citrullinated peptide antibodies and 25-hydroxy vitamin D. ROC curve analysis and discriminant analysis were done to find correlations between the various indicators and the differences between the two syndromes. And establish discriminant function formula. Results The IL-2R, IL-8, TNF-α and CRP have difference (P<0.05) between dampness-heat and cold-dampness blockage syndrome the two types of rheumatoid arthritis patients. The ROC graph for dampness-heat blockage syndrome as the goal shows the area under the curve of order was IL-2R> IL-8> TNF-α> CRP (P<0.05). For the discriminant function of the above four items discriminant analysis, the correct object back substitution probability is 73.8%, cross-verification method shows that the probability of correct identification was 72.5%. Conclusion The IL-2R, IL-8, TNF-α and CRP can be used as dampness-heat and cold-dampness blockage syndrome RA objective typing basis, and IL-2R and TNF-α are more significant than the other indicators.关键词
类风湿关节炎/湿热痹阻型/寒湿痹阻型/客观化Key words
rheumatoid arthritis/dampness-heat blockage syndrome/cold-dampness blockage syndrome/objectification分类
医药卫生
