临床骨科杂志2016，Vol.19Issue(5)：567-569,3.DOI:10.3969/j.issn.1008-0287.2016.05.022
巴曲亭应用于全髋关节置换术对手术出血的影响
The effect of batroxobin on bleeding during the total hip arthroplasty
邓波 1王静成 2熊传芝 3颜连启 3孙钰3
作者信息
- 1. 大连医科大学研究生院2014级，辽宁 大连 116000
- 2. 江苏省苏北人民医院骨科，江苏 扬州 225001
- 3. 江苏省苏北人民医院骨科，江苏 扬州 225001
- 折叠
摘要
Abstract
Objective To explore effect of the use of batroxobin to treat the hemorrhage during the total hip arthro-plasty(THA). Methods Sixty-two patients underwent THA were randomly divided into treatment group (32 cases) and control group (30 cases). Both groups of patients were applied for low molecular heparin anticoagulant therapy preoperatively, treatment group were used 2 U batroxobin dissolved in 5 ml of normal saline, preoperative intravenous injection before 10 min cut skin, intraoperative grinding acetabulum and enlarge pulp using 2 U batroxobin and 20 ml of normal saline local spray to cut bone cutting surface. Control group 10 min before cutting leather injection with preo-perative dose of normal saline, intraoperative grinding acetabulum and enlarge pulp using 20 ml saline local spray to bone cutting surface. Intraoperative bleeding and postoperative drainage volume of 24 h, preoperative and postopera-tive 24 h prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time(APTT), fibrinogen ( FIB) were compared. Two groups of patients were reexamed lower extremity deep vein thrombosis( DVT) on postop-erative three days, and were reviewed the hospital stay. Results The volume of intraoperative blood loss in treatment group(325. 14 ± 85. 21)ml was significantly lower than the control drain and detection in patients group (513. 45 ± 102. 05) ml (P<0. 05). After 24 hours to drain (251. 21 ± 74. 08) ml significantly lower than the control group (356. 35 ± 101. 29)ml(P<0. 01); two groups of patients with postoperative and dostoperative 24 h PT, TT and APTT were longer than before, but there was no statistically significant difference in treatment group ( P>0. 05 ) , control group was statistically significant difference ( P <0. 05 ) , postoperative and dostoperative 24 h FIB of two group were compared with the preoperative decl-ine, but there was no statistically significant difference in treatment group (P>0. 05), the control group difference was statistically significant (P<0. 05). The treatment group patients found in 2 cases lower extremity DVT and 1 case of deep hematoma on the third day, control group found 1 case of lower extremity DVT, no obvious difference was found between two groups of patients in hospital time (P>0. 05). Conclusions The batroxobin can reduce intraoperative blood loss and postoperative flow,it do not affect the patient′s blood coagulation effect, curative effect and securiy.关键词
全髋关节置换术/巴曲亭/出血量Key words
total hip arthroplasty/batroxobin/blood loss分类
医药卫生引用本文复制引用
邓波,王静成,熊传芝,颜连启,孙钰..巴曲亭应用于全髋关节置换术对手术出血的影响[J].临床骨科杂志,2016,19(5):567-569,3.
