临床骨科杂志2016，Vol.19Issue(5)：570-572,3.DOI:10.3969/j.issn.1008-0287.2016.05.023
不同方式使用氨甲环酸对全膝关节置换术后出血的影响及其安全性
The impact and safety analysis in different using mode of tranexamic acid of blood loss after ;total knee arthroplasty
高宏梁 1黄胜 1管国华 1吴锋锋 1李建有1
作者信息
- 1. 湖州市中心医院骨科，浙江 湖州 313000
- 折叠
摘要
Abstract
Objective To investigate the impact and safety analysis of different using mode of tranexamic acid in blood loss after total knee arthroplasty( TKA) . Methods To analysis total data of 154 cases who received TKA. Lo-cal application with intravenous infusion of 52 cases were divided into group A, local application of 53 cases into group B, and 49 cases who didn′t use of tranexamic acid into group C. The postoperative wound drainage volume, blood transfusion rate, blood transfusion volume, the hemoglobin level and D-Dimer measured on the first and third day, deep vein thrombosis,pulmonary embolism were compared among the three groups. Results The postoperative wound drainage and blood transfusion volume were lower in group A compared with group B and C(P<0. 05), group B was lower than group C(P<0. 05). The hemoglobin level measured on the first and third day were higher in group A compared with group B and C(P<0. 05), group B was higher than group C(P<0. 05). The D-Dimer measured on first and third day, deep vein thrombosis,pulmonary embolism was not significant among the three groups( P>0. 05 ) . Conclusions Local application with intravenous infusion and local application of tranexamic acid can reduce the blood loss in TKA with no increase of deep vein thrombosis and pulmonary embolism.关键词
氨甲环酸/关节成形术,膝/出血Key words
tranexamic acid/arthroplasty,knee/hemorrhage分类
医药卫生引用本文复制引用
高宏梁,黄胜,管国华,吴锋锋,李建有..不同方式使用氨甲环酸对全膝关节置换术后出血的影响及其安全性[J].临床骨科杂志,2016,19(5):570-572,3.
