临床口腔医学杂志2016，Vol.32Issue(10)：586-590,5.DOI:10.3969/j.issn.1003-1634.2016.10.003
硼、镁较优抗氟剂量的确定及联合应用预防小鼠氟牙症的研究
The determination of better anti-fluorine element dose and the research of combined application for B and Mg about prevention of dental fluorosis in mice
郭海燕 1侯铁舟2
作者信息
- 1. 山西省儿童医院口腔科 山西 太原 030013
- 2. 西安交通大学口腔医院 陕西 西安 710004
- 折叠
摘要
Abstract
Objective:To screen the better anti-fluorine element dose and to compatibility optimize through adding microelement Mg,B in feeder and observing the mitigatory degree of dental fluorosis.Methods:120 male ICR mice were ran-domly separated to 12 groups,blank group mice drank the distilled water,Fluorine group mice drank the distilled water con-taining sodium fluoride 110 mg/L,both of them ate common feeder.magnesium sulfate(MgSO4・ 7 H2 O)and sodium tetrabo-rate( Na2 B4 O7・ 10 H2 O) were assigned to feeder according to different dose and drinking as fluorine group.To observe the growth rate of body weight and tooth length,formative time of dental fluoros,formative grade and final grade in the experiment period.Results:the formative time mean of MgSO4・ 7 H2 O 162.5 mg/kg feeder and Na2 B4 O7・ 10 H2 O 884.74 mg/kg feeder groups were obviously later than fluorine group.The forming grade mean and final grade mean of fluorine group were obviously lower than fluorine group and other dose groups.Na2 B4 O7・ 10 H2 O 878.55 mg/kg feeder was the best dose among elements applied to anti-fluorine effect alone.Conclusion:162.5 mg/kg MgSO4 feeder was the better anti-fluorine dose group in magnesium experiment groups and 878.55 mg/kg sodium tetraborate feeder was the best among all elements applied to an-ti-fluorine effect alone.The effects that Mg-B associated application applied to anti-fluorine effect alone were inferior to Na2 B4 O7・ 10 H2 O 878.55 mg/kg feeder dose group.关键词
氟斑牙/镁/硼/拮抗作用Key words
Dental fluorosis/Magnesium/Boron/Antagonism分类
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郭海燕,侯铁舟..硼、镁较优抗氟剂量的确定及联合应用预防小鼠氟牙症的研究[J].临床口腔医学杂志,2016,32(10):586-590,5.
