农药学学报2016，Vol.18Issue(5)：556-566,11.DOI:10.16801/j.issn.1008-7303.2016.0080
4''-脱氧阿维菌素脲类及硫脲类衍生物的合成与杀虫活性
Synthesis and insecticidal activity of 4''- deoxy-abamectin urea and thioure analogues
摘要
Abstract
Based on SAR investigation, two series of abamectin analogues containing urea and acyl thiourea groups were designed according to analog synthesis and sub-structure. Their structures were confirmed by1H NMR, MS and elemental analysis. Their insecticidal activity was tested against Tetranychus cinnabarinus andBrevicoryne brassicae. All the tested compounds showed significant inhibitory activity against the above two insect species. Notably, the majority of those compounds exhibited high selectivity againstB. brassicae, some of which were much better in comparison to abamectin. Especially, compound9h displayed more potent activity than abamectin against the above two insect species, namely,T. cinnabarinus (LC50 = 0.100 μmol/L) andB. brassicae (LC50 = 1.71 μmol/L).Moreover, compound9o showed superior activity againstB. brassicae, with LC50 value of 1.13 μmol/L.关键词
阿维菌素 B1a/脲/硫脲/合成/杀虫活性Key words
abamectin/urea/acyl thiourea/synthesis/insecticidal activity分类
农业科技引用本文复制引用
张娜,成丕乐,南祥,吴小兵,刘映前,余海涛,张健,杨程杰,胡冠芳..4''-脱氧阿维菌素脲类及硫脲类衍生物的合成与杀虫活性[J].农药学学报,2016,18(5):556-566,11.基金项目
国家自然科学基金项目(31371975；30800720) （31371975；30800720）
