实用医学杂志2016，Vol.32Issue(17)：2857-2860,4.DOI:10.3969/j.issn.1006-5725.2016.17.022
心型脂肪酸结合蛋白和N-末端脑钠肽前体在脓毒症心肌损伤中的变化及意义
Changes and significance of heart-type fatty acid-binding protein and N terminal probrain natriuretic peptide in sepsis patients with myocardium injury
摘要
Abstract
Objective To investigate the clinical value of heart-type fatty acid-binding protein ( H-FABP) and N terminal probrain natriuretic peptide (NT-proBNP) in sepsis patients with myocardium injury. Methods 118 sepsis patients were included as survivor group (68 cases) and death group (50 cases) according to their prognosis outcome. 50 healthy people were selected as control group. Creatase, H-FABP, NT-proBNP, APACHEⅡscore and 28 day morbidity of control group and sepsis patients were assessed at 1 h, 6 h after admission by physical examination . Results At 1 h after admission , APACHEⅡscore , H-FABP and NT-proBNP level in sepsis patients were significantly higher than control group (P < 0.05); APACHEⅡscore, H-FABP, NT-proBNP and cTnI level at 6 h after admission were higher than that at 1 h (P < 0.05); APACHEⅡscore, H-FABP and NT-proBNP level in death group were higher than survivor group at 1, 6 h after admission (P < 0.05), cTnI level at 6 h after admission was higher in death group (P < 0.05). Futhermore, H-FABP, NT-proBNP and cTnI at 6 h after admission were positively correlated with each other (both P < 0.05). At 6 h after admission , H-FABP showed a better predictive value of 28-day mortality than NT-proBNP and APACHEⅡscore (P < 0.05). Conclusion H-FABP and NT-proBNP may suggest important significance in early diagnosis and prognosis prediction of sepsis patients with myocardium injury.关键词
脓毒症/心肌损伤/心型脂肪酸结合蛋白/N-末端脑钠肽前体Key words
Sepsis/Myocardium injury/Heart-type fatty acid binding protein/N terminal probrain natriuretic peptide引用本文复制引用
齐洪娜,张建军,何佳起,王维展,李雅琴..心型脂肪酸结合蛋白和N-末端脑钠肽前体在脓毒症心肌损伤中的变化及意义[J].实用医学杂志,2016,32(17):2857-2860,4.基金项目
衡水市科学技术研究与发展计划项目 （）
