实用医学杂志2016，Vol.32Issue(18)：3019-3022,4.DOI:10.3969/j.issn.1006-5725.2016.18.021
非酒精性脂肪性肝炎患者血清CK-18 M30水平测定的意义
Clinical value of Serum CK-18 M30 levels in patients with nonalcoholic steatohepatitis
摘要
Abstract
Objective To detect the level of serum fragmented cytokeratin 18 (CK-18 M30) in patients with nonalcoholic steatohepatitis (NASH), to explore the relationship between the expression of CK-18 M30 and NASH. Methods 33 healthy people as control group, 24 nonalcoholic simple fatty liver (NAFL) patients, and 21 NASH patients were included in this study. CK-18 M30, ALT, AST and GGT were detected in all patients’ vein blood. NAFLD activity points (NAS) was examined in biopsy specimens of NAFL patients and NASH patients. Pearson correlation was applied to analyze the correlations between serum CK-18 M30, ALT, AST, GGT and the NAS of liver tissue in NASH group. Results Serum CK-18 M30 level of healthy control, NAFL and NASH group were (96.557 2 ± 41.226 8)U/L, (104.321 7 ± 45.167 3)U/L, (263.125 5 ± 61.578 1)U/L respectively. Serum CK-18 M30 level in NASH patients positively correlated with both NAS of liver tissue and serum ALT, which correlation coefficient r values were 0.601 5 and 0.420 6. Conclusion The concentration of serum CK-18 M30 could be used as a marker in the diagnosis of NASH.关键词
非酒精性脂肪性肝炎/血清细胞角蛋白片段(CK-18 M30)/非酒精性单纯性脂肪肝Key words
Nonalcoholic steatohepatitis/Serum fragmented cytokeratin 18 (CK-18 M30)/Nonalcoholic simple fatty liver引用本文复制引用
齐凤祥,江勇,张颖,宓余强,徐亮,宋国栋..非酒精性脂肪性肝炎患者血清CK-18 M30水平测定的意义[J].实用医学杂志,2016,32(18):3019-3022,4.基金项目
天津市卫生局科技基金项目（编号2015KZ093）；天津市卫生局科技基金攻关项目（编号12KG119）；天津市卫生和计划生育委员会中医中西医结合科研课题 （）
