实用医学杂志2016，Vol.32Issue(18)：3023-3026,4.DOI:10.3969/j.issn.1006-5725.2016.18.022
T－SPOT.TB对免疫低下合并结核性胸膜炎患者的诊断价值
Diagnostic value of T-SPOT.TB for tuberculous pleurisy in immunocompromised patients
摘要
Abstract
Objective To explore the clinical value of tuberculous infection of T cells spot test (T-SPOT. TB)for diagnosing tuberculous pleurisy in immunocompromised patients. Methods The sensitivities of T-SPOT. TB,ADA, TB-DNA and tuberculosis antibodies to tuberculous pleurisy in 54 immunocompromised patients were compared.Among these patients,22 were retested by T-SPOT. TB after 2 months anti-tuberculosis treatment. Spot forming cells(SFCs) were compared before and after treatment. Results The diagnostic sensitivity of T-SPOT.TB (79.63%)was significantly higher than those of ADA (64.81%),TB-DNA (48.15%)and tuberculosis antibodies (55.56%) (P<0.05).22 patients were retested by the T-SPOT.TB after anti-TB treatment (2 months), the results showed that the positive rate of T-SPOT.TB was 90.91%,not significantly than previous tests (P<0.05).Both ESAT-6 and CFP-10 specific SFCs decreased significantly compared with those before anti-TB treatment (t=2.728 and 2.400,P<0.05 respectively). Conclusions T-SPOT.TB assay has satisfactory sensitivity and could be used in diagnosis of tuberculous pleurisy in immunocompromised patients.关键词
结核性胸膜炎/免疫低下/T-SPOT.TB/诊断Key words
tuberculous pleurisy/immunocompromised/T-SPOT.TB/diagnosis引用本文复制引用
贾文青,刘莹..T－SPOT.TB对免疫低下合并结核性胸膜炎患者的诊断价值[J].实用医学杂志,2016,32(18):3023-3026,4.基金项目
河南省医学科技攻关项目基金资助 （）
