实用医学杂志2016，Vol.32Issue(18)：3053-3056,4.DOI:10.3969/j.issn.1006-5725.2016.18.031
HPV E6／E7联合液基细胞学检查在宫颈癌前病变筛查中的意义
Clinical significance of HPV E6/E7 mRNA test combining TCT test to detect early cervical dysplasia
摘要
Abstract
Objective To investigate the value of HPV E6/E7 mRNA test combining liquid-based cytology test in cervical cancer screening. Methods A total of 377 samples from Wenzhou People's Hospital from June 2014 to September 2015 were collected and screened by HPV E6/E7 mRNA test combining with liquid-based cytology test , and the results was compared with the findings from the gold criteria of histology and pathology. Results The combination of HPV E6/E7 mRNA test and liquid-based cytology test can enhance the testing sensitivity and specificity. The sensitivity of the combination of HPV E6/E7 mRNA test and liquid-based cytology test for the diagnosis of LSIL was 94.41%, and that for the diagnosis of HSIL was 96.36%. Based on the gold criteria of histology and pathology , the sensitivity , specificity , positive-predictive value and negative predictive value of HPV E6/E7 mRNA test for the diagnosis of HSIL was 90%, 60.67%, 48.53% and 92.49%respectively. The sensitivity, specificity, positive-predictive value and negative- predictive value of liquid-based cytology test for the diagnosis of HSIL was 72.73%, 75.28%, 54.79% and 87.01% respectively. Conclusions The sensitivity of HPV E6/E7 mRNA test is superior to that of liquid-based cytology test , while the specificity of HPV E6/E7 mRNA test is inferior to that of liquid-based cytology test. The negative predictive value of HPV E6/E7 mRNA test is more meaningful than that of liquid-based cytology test. The combination of HPV E6/E7 mRNA test and liquid-based cytology test can enhance the testing sensitivity , but it does not increase the specificity.关键词
宫颈癌前病变/HPVE6/E7mRNA检测/低级别鳞状上皮内病变/高级别鳞状上皮内病变/液基细胞学Key words
Early cervical dysplasia/HPV E6/E7 mRNA detection/Low-grade squamous intraepithelial/High-grade squamous intraepithelial/Liquid-based cytology引用本文复制引用
夏作利,陈国荣,潘丹,林萍,金茹..HPV E6／E7联合液基细胞学检查在宫颈癌前病变筛查中的意义[J].实用医学杂志,2016,32(18):3053-3056,4.基金项目
温州市卫生局课题 （）
