实用医学杂志2016，Vol.32Issue(19)：3130-3132,3.DOI:10.3969/j.issn.1006-5725.2016.19.005
瘦素、脂代谢紊乱与妊娠期糖尿病的关系
Relationship between leptin, lipid metabolic disorder and gestational diabetes mellitus
摘要
Abstract
Objective To discuss the relationship between and value of Leptin with disorder of lipid metabolism in gestational diabetes mellitus. Method Research objects are divided into three groups including GDM group, normal glucose tolerance group (NGT group), normal non-pregnant group. Blood lipid, fasting blood glucose, fasting insulin, serum leptin and placental leptin levels were detected and HOMA-IR was calculated. Result (1) Serum leptin, TC, TG, placental leptin and HOMA-IR in GDM group were higher than those of NGT group and TC, serum leptin and HOMA-IR of NGT group were higher than those of control group. There were statistical significances (P<0.05). (2)Serum leptin levels were positively correlated with BMI, HOMA-IR, TC and TG respectively (r = 0.593, 0.688, 0.722, 0.492 respectively, P < 0.05). Conclusion Leptin may cause lipid metabolism disorders, and together they participate in the pathogenesis of GDM. Maternal serum leptin level is expected to become an observation index of GDM.关键词
妊娠期糖尿病/瘦素/血脂Key words
Gestational diabetes mellitus/Leptin/Blood lipid引用本文复制引用
李静芳,付艳芹,张苏河..瘦素、脂代谢紊乱与妊娠期糖尿病的关系[J].实用医学杂志,2016,32(19):3130-3132,3.基金项目
河南省医学科技攻关计划项目 （）
