实用医学杂志2016，Vol.32Issue(19)：3164-3167,4.DOI:10.3969/j.issn.1006-5725.2016.19.014
乙醇通过抑制NLRP3炎性小体减轻冠状动脉粥样硬化
Ethanol inhibiting the NLRP3 inflammasome activation to protect coronary heart disease
周婧 1姜迎萍 1赵一俏1
作者信息
- 1. 510120 广州市，广东省第二人民医院康复医学科，心血管内科
- 折叠
摘要
Abstract
Objective To examine whether ethanol modulates the intracellular processes involved in the secretion of IL-1α,and then exert a protective effect against coronary heart disease. Methods THP-1 cells in human were cultured for 2-3 generations , and put in PMF for 72 h to induce THP-1 into macrophage. ELISA was applied to detect effects for secretion of IL-1α by LPS, cholesterol and ethanol. In the light of ELISA re-sults, western blot was applied to detect the effects of ethanol on caspase-1 and NLRP3. Results Compared with the control group, the secretion of IL-1α in LPS group and LPS + CHOL group increased. Compared withLPS + CHOL group, the concentration of IL -1α in LPS + CHOL + etha group significantly decrease(P < 0.01). The results of western blot showed that ethanol significantly inhibited caspase-1 and NLRP3 activation. Conclu-sion Ethanol can inhibit the NLRP3 inflammasome activation in macrophages , which may represent a biological pathway underlying the protective effect of moderate alcohol consumption on coronary heart disease.关键词
冠状动脉粥样硬化/乙醇/IL-1α/NLRP3Key words
Coronary atherosclerosis/Ethanol/Interleukin-1α/NLRP3引用本文复制引用
周婧,姜迎萍,赵一俏..乙醇通过抑制NLRP3炎性小体减轻冠状动脉粥样硬化[J].实用医学杂志,2016,32(19):3164-3167,4.
