实用医学杂志2016，Vol.32Issue(20)：3296-3299,4.DOI:10.3969/j.issn.1006-5725.2016.20.003
抵抗素rs1477341和rs3219175与广东地区2型糖尿病的相关性
Correlations between resistin rs1477341, rs3219175 and type 2 diabetes mellitus in Guangdong
摘要
Abstract
Objective To explore the relationships between resistin rs1477341 , rs3219175 and type2 diabetes mellitus (T2DM) in Guangdong. Methods 180 patients of diagnosed T2DM in the Second Affiliated Hospital of Guangzhou Medical University from January 2013 to December 2014 were enrolled in the study as the treatment group and another 180 subjects taking health examination as the control group. The genotype distributions of rs1477341 locus A/T, rs3219175 locus A/G were compared and the relationship between the genotypes and T2DM were anlysed by the logistic regression. Results The frequencies of the rs1477341, rs3219175 locus genotype reached the genetic equilibrium, showed their representativeness of a population group. The frequency distribution of rs1477341 genotype was statistically insignificant across the two groups (P > 0.05). The frequency of rs3219175 genotype AA+AG was decreased while genotype GG increased significantly compared to the control group (P < 0.05). The logistic regression results suggest genotype GG may increase disease risk of T2DM which the morbidity rate of AG homozygote was 0.630 times as high as that of GG homozygote (OR =0.630, 95%CI:0.405 ~ 0.980, P < 0.05) and the morbidity rate of GG homozygote was 1.551 times as higher as that of AA+AG homozygote (OR = 1.551, 95%CI:1.016 ~ 2.368, P < 0.05). Conclusions rs1477341 genotype has no correlation with T2DM among the population in Guangdong , but rs3219175 genotype does. GG may have a higher susceptibility to T2DM.关键词
2型糖尿病/抵抗素/单核苷酸多态性Key words
Type 2 diabetes mellitus/Resistin/Single nucleotide polymorphism引用本文复制引用
雷萌,许新强,欧阳舒婷,周强,陈波,冀天星,林桢..抵抗素rs1477341和rs3219175与广东地区2型糖尿病的相关性[J].实用医学杂志,2016,32(20):3296-3299,4.基金项目
广东省科技计划项目（编号2012B061700044）；广东省医学科研基金项目（编号A2012256）；广东省医学科研基金立项项目 （）
