实用医学杂志2016，Vol.32Issue(20)：3394-3397,4.DOI:10.3969/j.issn.1006-5725.2016.20.031
MACC1蛋白在鼻咽癌组织中的表达及与预后的关系
Expression of MACC1 in nasopharyngeal carcinoma and its relationship with prognostic significance
摘要
Abstract
Objective To explore the expression of Metastasis-associated in colon cancer-1 (MACC1) in patients with nasopharyngeal carcinoma (NPC), and its relationship with clinical pathologic characteristics and prognosis Methods The expression of MACC1 was detected in 130 cases of NPC and the relationship among the MACC1 expressions, clinical pathologic characteristics and prognosis of NPC was analyzed. Results Positive expression rate of MACC1was 68.5% in the NPC and MACC1 expression was associated with advanced T stages, lymph node metastasis and advanced clinical stages of NPC (P < 0.05). The results of Kaplan-Meier survival analysis showed that the five year overall survival rate in patients with positive expressions of MACC1 (45.9%) was significantly lower than that of those with negative expressions (73.7%) and the difference was statistically significant (P < 0.05), Cox multi-factor analysis results showed that MACC1 expression was an independent prognostic factor for NPC (P = 0.004). Conclusion MACC1 abnormal expression is closely related to the invasion and metastasis of NPC and it is expected to become a new target for gene therapy of NPC.关键词
鼻咽肿瘤/MACC1/浸润/转移/预后Key words
NPC/MACC1/Invasion/Metastasis/Prognosis引用本文复制引用
梁荣,聂少麟,谢小雪,朱苏雨,金和坤,吴峥,周菊梅..MACC1蛋白在鼻咽癌组织中的表达及与预后的关系[J].实用医学杂志,2016,32(20):3394-3397,4.基金项目
湖南省科学技术厅科技计划一般项目 （）
