现代妇产科进展2016，Vol.25Issue(10)：739-743,5.DOI:10.13283/j.cnki.xdfckjz.2016.10.004
hrHPV E6/E7 mRNA检测用于宫颈癌联合筛查的横断面研究
Cross-sectional study of hrHPV E6/E7 mRNA in cervical cotesting
李晓林 1刘莹 1范俊 1林静 2赵淑萍3
作者信息
- 1. 青岛大学附属青岛市立医院妇科中心，青岛 266071
- 2. 青岛市城阳区人民医院妇科，青岛 266100
- 3. 青岛妇女儿童医院妇科，青岛 266000
- 折叠
摘要
Abstract
Objective:To explore the clinical value of hrHPV E6/E7 mRNA in cervical cotesting,to research its performance in cervical cancer cotesting. Methods:6223 women for op-portunistic cervical cancer screening in Qingdao Municipal Hospital and Qingdao Chengyang People's Hospital gynecology clinic row were collect from Jan. 2013 to Dec. 2015. According to the cervical screening methods,patients were divided into three groups:LBC+HC2,LBC+HPV genotyping,LBC+E6E7. The accuracy of three cotesting strategies and cytology alone,including sensitivity,specificity, positive predictive value, negative predictive value, colposcopy referral rate,CIN2+/CIN3+ detection rate and AUC were compared. Results:The sensitivities,specific-ities,PPVs,NPVs,colposcopy referral rate,CIN2+/CIN3+ detection rates of LBC+E6E7 for CIN2+/CIN3+ were 91 . 28%、95 . 50%、56 . 07%、99 . 43%、9 . 64% 、5 . 40% and 93 . 10%、92. 06%、19. 29%、99. 85%、9. 64%、1. 86%,respectively. These outcome index were not sta-tistically different between three cotesting strategies ( P>0 . 05 ) . The AUC of LBC+E6 E7 for CIN2+/CIN3+ were 0 . 969 and 0 . 973 , higher than LBC statistically ( P<0 . 05 ) . Conclusion:The accuracy of hrHPV E6E7 mRNA and LBC contesting is as well as HC2,HPV typing cotest-ing with LBC so that it could be an alternative as HPV-DNA in cotesting program of opportunis-tic screening.关键词
宫颈筛查/人乳头瘤病毒/mRNAKey words
Cervical screening/Human papillomavirus/mRNA分类
医药卫生引用本文复制引用
李晓林,刘莹,范俊,林静,赵淑萍..hrHPV E6/E7 mRNA检测用于宫颈癌联合筛查的横断面研究[J].现代妇产科进展,2016,25(10):739-743,5.
