中国组织工程研究2016，Vol.20Issue(44)：6564-6569,6.DOI:10.3969/j.issn.2095-4344.2016.44.004
关节腔内加压灌注氨甲环酸与初次全膝关节置换后失血量的关系
Blood loss in primary total knee replacement with intra-articular injection of tranexamic acid and presurization
陈群群 1陈建发 2周驰 2董路珏 2霍少川 1王海彬2
作者信息
- 1. 广州中医药大学附属骨伤科医院，广东省广州市 510240
- 2. 广州中医药大学第一附属医院，广东省广州市 510405
- 折叠
摘要
Abstract
BACKGROUND:Tranexamic acid is extensively used in the primary total knee replacement, but there are many different methods. OBJECTIVE:To explore the efficacy and safety of the intra-articular injection of tranexamic acid with pressurization in reducing the blood loss of primary total knee replacement. METHODS:Total y 56 patients undergoing unilateral total knee arthroplasty were enrol ed and randomly divided into two groups. Patients were given the intra-articular injection of 100 mL of saline solution dissolving 2.0 g of tranexamic acid with large pad pressure bandaging the knee, and 4-hour drainage tube close, and then underwent negative pressure suction (experimental group);differently, the controls were given the normal pad bandage group. The drainage tube was removed within 48 hours after replacement. The patient blood routine examination was performed at the 3rd day, and at the same time, the volume of drainage was recorded;and the color Doppler ultrasound in ipsilateral lower extremity veins was conducted to observe the incidence of thrombosis at 4-5 days. RESULTS AND CONCLUSION:(1) The total blood loss, postoperative dominant blood loss, and hidden blood loss in the experimental group were significantly less than those in the control group (P<0.05). (2) No significant difference was found in the incidence of postoperative thrombosis between two groups (P>0.05). (3) These results indicate that the intra-articular injection of tranexamic acid with pressurization can significantly reduce the postoperative blood loss in the primary total knee arthroplasty, without increasing the risk of deep vein thrombosis.关键词
骨科植入物/人工假体/氨甲环酸,膝关节置换,失血量/加压灌注分类
医药卫生引用本文复制引用
陈群群,陈建发,周驰,董路珏,霍少川,王海彬..关节腔内加压灌注氨甲环酸与初次全膝关节置换后失血量的关系[J].中国组织工程研究,2016,20(44):6564-6569,6.
