中国组织工程研究2016，Vol.20Issue(44)：6636-6642,7.DOI:10.3969/j.issn.2095-4344.2016.44.014
基于3D打印技术股骨头减压联合骨髓间充质干细胞移植专用移植器的研制及应用
Development and application of special-purpose grafter by femoral head decompression combined with bone marrow mesenchymal stem cells transplantation based on three-dimensional printing technology
摘要
Abstract
BACKGROUND:Autologous tissue-engineered bone marrow mesenchymal stem cel s (BMSCs) transplantation is one of the most common methods of treating early osteonecrosis of femoral head, but now there is stil no any special-purpose grafter available in the market. Such surgical transplantation is a laborious, time-consuming and tedious process, which goes against its clinical promotion. OBJECTIVE:To develop a supporting, efficient, special-purpose grafter, to solve the difficulty in stem cel s transplantation during core decompression of femoral head. METHODS:CAD software was used to perform solid modeling for this special-purpose grafter and print them by three-dimensional (3D) fast printing technology. The performance of this special-purpose grafter was tested by femoral head core decompression combined with BMSCs transplantation. It was compared with traditional surgical instrument in terms of duration of operation, intraoperative blood loss, visual analogue scale (VAS) of stem cel/biological fiber col agen complex omission amount and doctor’s satisfaction score. RESULTS AND CONCLUSION:(1) A kind of special-purpose grafter was developed by 3D printing technology rapidly. (2) Compared with the control group, duration of operation, intraoperative blood loss, VAS scores and doctor’s satisfaction scores were significantly improved in the trial group (P<0.05). (3) CAD software combined with 3D printing technology is a highly efficient means for front-line clinicians to perform independent development. The research and development of this special-purpose grafter provides a perfect solution to the laborious, time-consuming and tedious process of cel/biological col agen fiber transplantation.关键词
骨科植入物/骨植入物/移植器/3D打印技术/计算机辅助设计软件/骨组织工程/骨髓间充质干细胞/生物材料复合物/股骨头坏死/髓芯钻孔减压/医疗器械/国家自然科学基金分类
医药卫生引用本文复制引用
王建吉,马敏先,叶川,杨龙,李靖,孙琦,左威敏,任其逢,孙宇,吴展羽,邹强..基于3D打印技术股骨头减压联合骨髓间充质干细胞移植专用移植器的研制及应用[J].中国组织工程研究,2016,20(44):6636-6642,7.基金项目
国家自然科学基金(81360232)；贵阳市科技计划项目(2014100135)@@@@the National Natural Science Foundation of China, No.81360232 （81360232）
the Science and Technology Project of Guiyang City, No.2014100135 （）
