中国组织工程研究2016，Vol.20Issue(44)：6673-6681,9.DOI:10.3969/j.issn.2095-4344.2016.44.020
骨微结构与微损伤检测方法的研究与进展
Research progress of bone microarchitecture and microdamage detection
摘要
Abstract
BACKGROUND:Bone fragility and poor bone quality due to osteoporosis are a major and increasing concern. Bone microarchitecture and microdamage, the important factors of bone quality, their detection technology and instrument have experienced a long development process. OBJECTIVE:To give a brief introduction of the concept of the bone microarchitecture and microdamage, then to summarize the research progress of their detective methods. METHODS:PubMed and CNKI databases were retrieved for reviews and articles related to bone microarchitecture and microdamage published from January 1990 to June 2016 using the keywords of“bone microarchitecture, bone microdamage and detect/detective/detecting”in Chinese and English, respectively. Finaly a total of 65 articles were selected for overview. RESULTS AND CONCLUISON:(1) Bulk staining is a quick and useful way to confirm and assess linear microcracks and diffuse damage. Micro-CT and confocal microscopy al ow visualization at the micron scale, and are useful tools to understand the three-dimentional nature of bone microdamage. Scanning electron microscope lacks the ability to investigate large regions of microdamage, but al ows users to probe in extensive details at the nano scale. (2) Ultimately, we recommend the use of multiple imaging modalities according to the experimental needs to obtain useful information about bone quality and microdamage formation, across the scales of hierarchy in bone.关键词
骨科植入物/骨植入物/骨微结构/骨微损伤/检测方法/国家自然科学基金分类
医药卫生引用本文复制引用
许灿,李明清,王成功,李康华,刘华..骨微结构与微损伤检测方法的研究与进展[J].中国组织工程研究,2016,20(44):6673-6681,9.基金项目
国家自然科学基金(81301543)@@@@the National Natural Science Foundation of China, No.81301543 （81301543）
