中国老年保健医学2016，Vol.14Issue(5)：3-7,5.DOI:10.3969/j.issn.1672-4860.2016.05.001
小神经胶质细胞在阿尔兹海默症中的病因学作用
The etiology mechanism of microglia in the development of Alzheimer's disease
摘要
Abstract
Alzheimer's disease ( AD) is the most common progressive neurodegenerative disease caused by the accumulation of A βol-igomer and hyperphosphorylated tau protein in the brain .Based on the onset age , the AD could be classified into the early-onset Alzheimer's disease ( EOAD) and the late-onset Alzheimer 's disease ( LOAD) .With the progress of the studies of AD ,a plenty of resear-ches reveal that the neuroinflammation triggered by the microglia and several genetic factors of microglia act a pivotal role in the develop -ment of AD.In this paper ,we review the etiology mechanism of microglia in AD .关键词
小神经胶质细胞/阿尔茨海默症/炎症反应/遗传因素Key words
microglia/Alzheimer's disease/neuroinflammation/genetic factors引用本文复制引用
韩宇浩,陈超,李志鹏,杨泽..小神经胶质细胞在阿尔兹海默症中的病因学作用[J].中国老年保健医学,2016,14(5):3-7,5.基金项目
国家自然科学基金（81061120527，81370445，81472408），卫生部公益性研究基金（201302008）和国家科技部十二五支撑计划（2012BAI10B01，2015BAI06B03）。 （）
