中国老年保健医学2016，Vol.14Issue(5)：8-10,11,4.DOI:10.3969/j.issn.1672-4860.2016.05.002
Tau蛋白的磷酸化对阿尔兹海默症影响的相关研究
Related research on the phosphorylation of Tau protein effect on Alzheimer's disease
摘要
Abstract
Alzheimer's disease is a kind of common chronic progressive neurodegenerativing disease ,primarily manifested as irreversi-ble whole brain damage.Because of complicated factors ,nosogenesis has not been determined .One kind of theory is that abnoraml Tau protein phosphorylation and straight filament will lead to NFTs .This caused microtubule deformation in the neurofibrillary .Then neuronal will degeneration and even death .When lots of neuronal death that would trigger AD .Therefore it's important to find out the mechanism of abnormal phosphorylation of Tau protein and then targeted therapy for patients .关键词
阿尔兹海默症/Tau蛋白/神经纤维缠结Key words
Alzheimer's disease/Tau protein/NFTs引用本文复制引用
刘晏伊,陈超,李志鹏,杨泽..Tau蛋白的磷酸化对阿尔兹海默症影响的相关研究[J].中国老年保健医学,2016,14(5):8-10,11,4.基金项目
国家自然科学基金（81061120527，81370445，81472408），卫生部公益性研究基金（201302008）和国家科技部十二五支撑计划（2012BAI10B01，2015BAI06B03）。 （）
