摘要
Abstract
Objectives To study the expression of basic fibroblast growth factor ( bFGF ) and multidrug resistance protein 1 (MRP-1) in gastric cancer (GC) tissue and their relationship.Methods immunohistochemical staining (SP method) detecting the patients on chronic superficial gastritis(CSG) 25 cases,Intestinal metaplasia(IM) 45 cases,50 cases of dysplasia (dys) and positive expression of 65 cases GC tissue specimens in bFGF and MRP-1.RT-PCR technology to detect the expression of MRP-1mRNA.The mean compared with t-test,the sample was compared with χ2-test,linear correlation analysis with correlation analysis of two factors . Results In the process of CSG ,IM,Dys,GC,bFGF,MRP-1 expression was gradually increasing ,bFGF,MRP-1 positive expression rate of GC group to Dys,IM group,the difference was statistically significant (P<0.05).MRP-1 expression intensity was positively correlated with MRP-1mRNA (r =0.598,P <0.05).Conclusions bFGF,MRP-1,MRP-1mRNA expression was gradually in-creased during the formation of gastric cancer .关键词
胃癌/免疫组织化学染色/碱性成纤维细胞生长因子/多耐药相关蛋白1/逆转录-聚合酶链反应Key words
gastric cancer/immunohistochemistry/bFGF/MRP-1/RT-PCR
