中国医学前沿杂志（电子版）2016，Vol.8Issue(9)：133-136,4.DOI:10.12037/YXQY.2016.09-23
醋酸奥曲肽联合奥美拉唑治疗肝硬化门静脉高压所致上消化道出血的临床效果及对血流的影响
Effects on hemodynamics and hemostasia effect exploration of octreotide acetate combined with omepra-zole in the treatment of upper gastrointestinal bleeding caused by cirrhosis
王芳 1陈随才 1曹娜娅1
作者信息
- 1. 榆林市第二医院 消化科，陕西 榆林 719000
- 折叠
摘要
Abstract
Objective To explore the effects on hemodynamics and hemostasia effect of octreotide acetate combined with omeprazole in the treatment of upper gastrointestinal bleeding caused by cirrhosis. Method 96 cases of upper gastrointestinal bleeding caused by cirrhosis in our hospital from December 2012 to December 2015 were randomly divided into combination group and control group, 48 cases in each group. Patients in combination group were treated with octreotide acetate combined with omeprazole, patients in control group were treated with omeprazole, patients in the two groups were treated for 7 days. The levels of glucagon, serum NO, portal venous flow and spleen venous flow, average hemostasis time, 48 hours recurrent bleeding rate before and after treatment were compared between the two groups. Result The level of glucagon and serum NO in combination group were obviously lower than those in control group at 2 hours after first dose (P<0.01);the portal venous flow and spleen venous flow in combination group were markedly less than those in control group at the end of the treatment (P < 0.01);average hemostasis time and 48 hours recurrent bleeding rate of combination group were less than control group (P < 0.01), the total effective rate of combination group was higher than control group (P < 0.05). Conclusion Octreotide acetate combined with omeprazole in the treatment of upper gastrointestinal bleeding caused by cirrhosis has shorter bleeding time, protect gastric mucosa, reduce portal vein pressure, improve collateral circulation and prevent recurrent bleeding.关键词
肝硬化/上消化道出血/醋酸奥曲肽/奥美拉唑Key words
Cirrhosis/Upper gastrointestinal bleeding/Octreotide acetate/Omeprazole引用本文复制引用
王芳,陈随才,曹娜娅..醋酸奥曲肽联合奥美拉唑治疗肝硬化门静脉高压所致上消化道出血的临床效果及对血流的影响[J].中国医学前沿杂志（电子版）,2016,8(9):133-136,4.
