中国中医药信息杂志2016，Vol.23Issue(11)：75-77,3.DOI:10.3969/j.issn.1005-5304.2016.11.018
黄连对脾虚大鼠胃肠运动功能及胃动素、胃泌素的影响
Effects of Coptidis Rhizoma on Gastrointestinal Motility Functions, MTL and GAS in Spleen-deficiency Rats
摘要
Abstract
Objective To observe the effects of Coptidis Rhizoma on gastrointestinal motility functions, MTL and GAS in spleen-deficiency rats; To explore the dose-effect mechanism of “invigorating stomach” and “spoiling appetite”.Methods Fatigue and troublesome were used to establish exhausted spleen-deficiency models. 60 SD rats were randomly divided into blank control group, model group, positive medicine group, Coptidis Rhizoma high-, medium- and low-dose groups, with 10 rats in each group. Each medication group received relevant medicine for gavage, while the blank control group and model group received normal saline for gavage, once a day for 14 d. The general gastrointestinal motility functions, MTL and GAS of rats in each group were observed.Results Compared with blank control group, the gastric residual rate of model group was significantly higher; small intestinal propulsion rate, MTL, and GAS were significantly lower (P<0.05,P<0.01). Compared with model group, the gastric residual rate in Coptidis Rhizoma low-dose group was significantly lower; small intestinal propulsion rate, MTL and GAS increased significantly (P<0.05,P<0.01); small intestinal propulsion rate and MTL in Coptidis Rhizoma high-dose group were significantly lower (P<0.05).Conclusion High-doseCoptidis Rhizoma leads to “spoiling appetite”, and low-dose Coptidis Rhizoma leads to “invigorating stomach”, which may be related to adjusting gastrointestinal motility directly or adjusting the secretion of gastrointestinal hormones.关键词
黄连/脾虚/胃肠运动/胃动素/胃泌素/大鼠Key words
Coptidis Rhizoma/spleen deficiency/gastrointestinal motility/MTL/GAS/rats分类
医药卫生引用本文复制引用
杨红莲,段玉红,钱笑音..黄连对脾虚大鼠胃肠运动功能及胃动素、胃泌素的影响[J].中国中医药信息杂志,2016,23(11):75-77,3.基金项目
国家自然科学基金 （）
陕西省自然科学基金 （）
