动物营养学报2016，Vol.28Issue(10)：3070-3075,6.DOI:10.3969/j.issn.1006-267x.2016.10.008
Wnt/β-连环蛋白信号通路在哺乳动物子宫发育中的调控作用及其机制
Regulation and Mechanism of Wnt/β-Catenin on the Development of Uterus in Mammals
摘要
Abstract
The orderly operation of the physiological activity program within the body depends on the coordina-tion among different signal transduction pathways. Wnt ( name derived from the Drosophila gene Wingless and mouse oncogene int-1) signaling pathway has received extensive attention of scholars and became a research hotspots in the fields of molecular biology and cell biology. In this paper, regulation and mechanism of Wnt/β-catenin signaling pathway on development of uterus in mammals were studied. The paper reviewed the regula-ting mechanism of glycogen synthase kinase 3β ( GSK-3β) , adenomatous polyposis coli ( APC ) , scaffold protein ( Axin) and osteoblast inhibitory factor ( Dkk) on Wnt/β-catenin signaling pathway and intranuclear activated of Wnt/β-catenin signaling pathway, to further revealed the regulating mechanism in the uterus, and provided reference for the treatment of uterine diseases.关键词
Wnt/β-catenin/子宫/GSK-3β/APC/Axin/Dkk/核内激活Key words
Wnt/β-catenin/uterus/GSK-3β/APC/Axin/Dkk/intranuclear activated分类
农业科技引用本文复制引用
杨立杰,杨维仁,黄丽波,冯强,姜淑贞,杨在宾..Wnt/β-连环蛋白信号通路在哺乳动物子宫发育中的调控作用及其机制[J].动物营养学报,2016,28(10):3070-3075,6.基金项目
国家自然科学基金资助项目(31572441) （31572441）
