中国耳鼻咽喉头颈外科2016，Vol.23Issue(9)：511-514,4.DOI:10.16066/j.1672-7002.2016.09.005
X线交叉互补修复基因3遗传变异与喉癌风险的相关性
Association between genetic polymorphism in DNA repair genes XRCC3 and risks of laryngeal carcinoma
摘要
Abstract
OBJECTIVE To study the association between polymorphism of DNA repair gene XRCC3Thr 241 Met and the risks of developing laryngeal carcinoma. METHODS Sixty patients with laryngeal carcinoma and 120 cancer-free controls were genotyped for the polymorphism by Multiplex SNaPshot.The odds ratios (ORs) and 95% confidence intervals (Cls) were calculated using unconditional logistic regression model.RESULTS The XRCC3 241 Met allele increased the risks of developing laryngeal carcinoma.Comparing with subjects having the XRCC3241 Thr/Thr genotype,the subjects at least having one XRCC3 241 Met allele had OR of 4.27 (95%CI 1.49-12.18). CONCLUSION XRCC3 Thr 241 Met plays an important role in the development of laryngeal carcinoma.关键词
喉肿瘤/DNA修复/变异(遗传学)/X线交叉互补修复基因3Key words
Laryngeal Neoplasms/DNA Repair/Variation (Genetics)/X-ray repair cross-complementing group 3引用本文复制引用
尼力帕尔•阿力木,王玲玲,张波,阿依恒•曲库尔汗..X线交叉互补修复基因3遗传变异与喉癌风险的相关性[J].中国耳鼻咽喉头颈外科,2016,23(9):511-514,4.基金项目
新疆自治区自然科学基金资助项目 （）
