中国耳鼻咽喉头颈外科2016，Vol.23Issue(10)：561-564,4.DOI:10.16066/j.1672-7002.2016.10.002
儿童变应性鼻炎舌下特异性免疫治疗的近期疗效观察
Short-term clinical efficacy of sublingual immunotherapy in children with allergic rhinitis
摘要
Abstract
OBJECTIVE To investigate the short-term clinical efficacy of sublingual immunotherapy in children with allergic rhinitis. METHODS Forty-four patients, from 3-14 years of age, with mite-sensitive allergic rhinitis were treated sublingually with standardized dermatophagoidesfarinae extract. After treatment of 3 or 6 months using the dermatophagoidesfarinae extract, the total nasal symptoms score(including nasal congestion, nasal itching, rhinorrhea and sneezing scores), total rhinitis medicine scores, visual analog scale scores and the percentage of blood eosinophilic granulocyte(Eos%) before and after treatment were evaluated. SPSS 20.0 software was used to analyze the data. RESULTS After 3 or 6 months' treatment,thenasal symptoms score(including nasal congestion, nasal itching, rhinorrhea and sneezing scores), total rhinitis medicine scores and visual analog scale scoreshad significantly reduced,comparing with that before treatment(all P<0.05). The comparison of the total nasal symptoms score(including nasal congestion, rhinorrhea and sneezing scores), total rhinitis medicine scores and visual analog scale scores between 3 months and 6 months treatment had shown no significant difference (all P>0.05), while nasal itching scores had significantly reduced(Z=-4.185, P<0.05). After 6 months' treatment, the percentage of Eos% had significantly reduced compared with that before treatment(Z=-4.544, P<0.05). CONCLUSION SLIT could be an effective treatment in patients with allergic rhinitis sensitive to house dust mite. It would have effect after3 months treatment and Eos%reduced significantly after 6 months treatment.关键词
投药,舌下/免疫疗法/粉尘螨/鼻炎,变应性,常年性/鼻炎,变应性,季节性/嗜酸细胞/儿童Key words
Administration, Sublingual/Immunotherapy/Dermatophagoides farinae/Rhinitis, Allergic, Perennial/Rhinitis, Allergic, Seasonal/Eosinophils/Child引用本文复制引用
王蓬鹏,唐力行,杨小健,葛文彤..儿童变应性鼻炎舌下特异性免疫治疗的近期疗效观察[J].中国耳鼻咽喉头颈外科,2016,23(10):561-564,4.基金项目
北京市教育委员会科技计划面上项目 （）
